Clinical Observation On The Combination Of Shugan Yangxue Prescription And Letrozole In The Treatment Of Ovulatory Disorders (liver Depression And Blood Deficiency Syndrome) In Polycystic Ovary Syndrom

Objective:In this study,the treatment of Polycystic Ovary Syndrome(PCOS)with liver stagnation and blood deficiency syndrome by using Shugan Yangxue Recipe combined with letrozole to compare the changes of TCM syndromes,ovulation rate,and pregnancy rate between the two groups.To explore its mechanism of action,and to compare its clinical efficacy and overall safety,to provide a theoretical basis for clinical treatment of this disease.Methods:By random and controlled clinical experiment method,60 patients who met the inclusion criteria were divided into a treatment group and a control group,with 30 cases in each group.The treatment group was treated with Shugan Yangxue Recipe combined with letrozole,and the control group was treated with letrozole.After continuous treatment for 3 menstrual cycles,the TCM symptom scores,follicle maturation,ovulation,and pregnancy rate were compared between the two groups before and after treatment..To evaluate the clinical efficacy and safety of Shugan Yangxue Recipe combined with letrozole in the treatment of polycystic ovary syndrome with ovulatory disorder.Results:1.In terms of clinical efficacy:in the treatment group,9 cases were cured,6 cases were markedly effective,13 cases were effective,2 cases were ineffective,and the total effective rate was 93.3%;in the control group,1 case was cured,9 cases were markedly effective,15 cases were effective,and 5 cases were ineffective.The effective rate is 83.3%.After statistical analysis,the difference in clinical efficacy between the two groups after treatment was statistically significant(P<0.05),indicating that the clinical efficacy of the treatment group was better than that of the control group.2.In terms of the efficacy of TCM syndromes:before treatment,the total score of TCM syndromes in the treatment group was(21.27±0.980)points,and the total score of TCM syndromes in the control group was(21.47±1.106)points;after treatment,the total score of TCM syndromes in the treatment group was(5.17±4.348)points,and the total score of TCM syndromes in the control group was(11.87±4.696)points.After statistical analysis,the total scores of the two groups were compared after treatment,and the difference was statistically significant(P<0.05),indicating that the therapeutic effect of TCM syndromes in the treatment group was significantly better than that in the control group.3.In terms of promoting follicle maturation:the treatment group received a total of 70 cycles of treatment,of which 45 cycles of follicles were mature and 25 cycles were immature;the control group was treated for a total of 82 cycles,of which 60 cycles of follicles were mature and 22 cycles of follicles were immature.Mature.After statistical analysis,there was no significant difference between the two groups after treatment(P>0.05),indicating that there was no difference in the curative effect of promoting follicle maturation between the two groups.4.In terms of ovulation rate and pregnancy rate:the ovulation rate in the treatment group was 70.0%,and the ovulation rate in the control group was 48.8%.After statistical analysis,the difference between the two groups after treatment was statistically significant(P<0.05),indicating that the ovulation rate in the treatment group was superior.in the control group.The pregnancy rate of the treatment group was 30.0%,and the pregnancy rate of the control group was 3.0%.According to statistical analysis,the difference between the two groups after treatment was statistically significant(P<0.05),indicating that the pregnancy rate of the treatment group was better than that of the control group.Conclusion:Shugan Yangxue Recipe combined with letrozole in the treatment of polycystic ovary syndrome patients with ovulatory disorder(liver stagnation and blood deficiency syndrome)has an exact curative effect than letrozole.