Study On TCM Syndrome Factors And Medication Rules For Coronary Microvascular Disease In Perimenopausal Wome

Objective: to explore the distribution characteristics of TCM syndrome elements and medication rules of coronary microvascular lesions in peri-menopausal women,so as to provide basis and reference for the prevention and treatment of this disease in the future.Methods: a retrospective study was conducted to collect the data of 343 peri-menopausal female patients with coronary microvascular diseases who were admitted to the Department of Cardiology of the first affiliated Hospital of University from November 2012 to November 2021.(1)TCM syndrome factor research: the general situation and four diagnostic information of the case were determined according to the "Syndrome Dialectics scale" of Zhu Wenfeng,and the disease location and disease syndrome factors were grade d,and then the clinical symptoms,tongue and pulse were recorded into the Excel table for frequency and frequency statistics.(2)study on the law of traditional Chinese medicine: the first prescriptions in the cases were recorded in the Excel table,and the frequency and frequency of the nature,taste,meridian tropism and efficacy of traditional Chinese medicine were counted.SPSSModeler18.0 software was used to analyze association rules,and SPSS23.0 software was used for cluster analysis and factor analysis of high-frequency drugs.Results:(1)Clinical symptoms:(1)The nature of pain: the coronary microvascular lesions of 343 peri-menopausal women involved 7 kinds of pain,and the highest frequency was stuffy pain,tingling pain and distending pain.(2)Seizure inducement: it involves 6 types,and the higher frequency is attack in resting state without inducement,attack after activity,attack when emotional agitation,attack after fatigue.(3)Clinical symptoms: a total of 61 symptoms are involved.the more frequent symptoms were chest tightness,shortness of breath,insomnia,dizziness,chest pain,fatigue,palpitation,dry mouth,sweating,anorexia,headache,pain radiating to the back,pain radiating to the shoulder,bitter mouth,cough,palpitation,nausea,poor spirit,heartache and so on.(2)tongue image: the tongue is mainly red,light red and dark red.The tongue coating is mainly yellow,thin,greasy and white.(3)Pulse: 21 kinds of pulse are involved,mainly string pulse,string veinlet and string slip pulse.The phase and pulse is divided into a single pulse,involving a total of 10 kinds of pulse,mainly chord pulse,veinlet and slippery pulse.(4)the distribution of syndrome elements in traditional Chinese medicine:(1)Disease location syndrome element: the main disease position syndrome element is heart > lung > liver > stomach > spleen.Compared with the syndrome element levels of each disease position,the heart was mainly in grade Ⅱ,and the others were in grade Ⅰ.In the total grade comparison,the disease location syndrome factor is mainly grade Ⅰ.(2)Disease syndrome elements: the main disease syndrome elements are qi deficiency > yin deficiency > qi stagnation > dampness > blood stasis > blood deficiency >phlegm.The comparison of the syndrome factors of each disease is mainly gradeⅠ.In the total grade comparison,the disease syndrome factor is mainly grade Ⅰ.(5)regular distribution of traditional Chinese medicine:(1)Frequency of traditional Chinese medicine: 343 first prescription,involving a total of 207 traditional Chinese medicines,of which the frequency of drug use was more than 30 times involving 45 kinds of traditional Chinese medicine.In turn:licorice,Pinellia,Bupleurum,Trichosanthes,Salvia miltiorrhiza,Ligusticum chuanxiong,Poria,Angelica,tangerine peel,Coptis chinensis,Radix Ophiopogonis,Radix Paeoniae Alba,Radix Scutellariae,Fructus Schisandrae,Radix Atractylodis,Radix Atractylodis,Fructus Aurantii,Radix Atractylodis,Radix Amomi,Radix Rehmanniae,Radix Amomi.Polygonum multiflorum,cassia twig,keel.(2)Medicinal properties: mainly warm,flat and slightly cold.(3)Medicine taste: sweet,pungent and bitter.(4)Meridian tropism: mainly lung,spleen,liver and heart meridian.(5)Efficacy: mainly for tonifying deficiency medicine > activating blood circulation and removing blood stasis medicine > resolving phlegm,relieving cough and relieving asthma medicine > regulating qi medicine > heat clearing medicine > antidote medicine > tranquilizing medicine > diuresis and dampness medicine.(6)Association rules: mainly Pinellia ternata,Trichosanthes;Pinellia,Coptis chinensis;Ophiopogon,Schisandra;Bupleurum,Fructus Aurantii.(7)Cluster analysis and factor analysis: highfrequency traditional Chinese medicine was classified into 6 categories by cluster analysis,which respectively had the functions of tonifying qi and invigorating spleen,resolving dampness and removing phlegm,calming heart and mind,calming liver and wind,clearing heat and resolving phlegm,promoting blood circulation and removing blood stasis.14 common factors were obtained by factor analysis.Conclusion:(1)In peri-menopausal women,insomnia,anorexia,fatigue,mental distress,dizziness and sweating are the most common clinical symptoms.Pain is mainly stuffy pain,and often occurs in resting state without inducement.(2)The syndrome elements of this disease are mainly in the heart,involving lung,liver,spleen and stomach;deficiency of disease syndrome elements are mainly qi deficiency and yin deficiency,but in fact they are mainly qi stagnation and dampness,involving blood stasis and phlegm.(3)The disease is mainly used to dissolve dampness and remove phlegm,tonify qi and invigorate the spleen,supplemented by soothing the liver and regulating qi,calming the heart and mind,activating blood circulation and relieving pain.Make good use of Pinellia ternata,Trichosanthes,tangerine peel,Poria,Bupleurum,Salvia miltiorrhiza,Ligusticum chuanxiong,Angelica,Radix Ophiopogonis,Fructus Schisandrae,Radix Paeoniae Alba,mostly related to Gualou Xiebai Banxia decoction,small sunken chest decoction,Shengmai Powder,Xuefu Zhuyu decoction.