| purpose:Collect the literature published in recent 30 years on the treatment of liver cancer with traditional Chinese medicine and its complications or adverse reactions after the intervention,summarize and summarize the use rules of classical and timely prescriptions,summarize and analyze the use of traditional Chinese medicine in the treatment of liver cancer and its complications or adverse reactions after the intervention with data mining technology and methods,and explore the use rules of drugs,And based on network pharmacology,explore the possible target and pathway of Dachaihu Decoction in the treatment of TACE postoperative embolism syndrome of liver cancer,so as to provide theoretical support for clinical rational prescription and experimental research.Material and method:1.Collect the literature on the treatment of liver cancer with traditional Chinese medicine and its complications or adverse reactions after intervention in recent 30 years from the establishment of China How Net database,Wanfang database and VIp database to August2021.Reasonably formulate the inclusion criteria and exclusion criteria,collect the literature according to the requirements,extract the formula compatibility and drug composition used in the selected literature,establish the corresponding complication or adverse reaction formula use database according to liver cancer and different intervention methods,and conduct the classic and timely treatment to explore the formula use law.Collect the literature containing probability in the literature for statistics,extract the probability information and the corresponding drugs used for statistics,analyze the drug use of probability,and explore the drug use rules and characteristics of liver cancer and its complications and adverse reactions after intervention,so as to guide clinical drug use.2.Using the method of network pharmacology to analyze the relevant targets and possible pathways of Dachaihu Decoction in the treatment of TACE postoperative embolism syndrome of liver cancer.Results:1.According to the search conditions,a total of 746 articles were retrieved,including 456 articles of CNKI,244 articles of Wanfang and 46 articles of VIP.Repeated literature,review literature,animal experiment literature and literature not mentioned in traditional Chinese medicine treatment were screened out.A total of 128 articles were included,including 91 articles of grade II,6 articles of grade III and 31 articles of grade V.A total of 119 prescriptions were involved,including 108 prescriptions of addition and subtraction of classic prescriptions and time prescriptions.Among them,45 involve the economic side and 63 involve the time side.The adverse reactions and complications involved include: embolism syndrome,gastrointestinal reaction,liver function injury,ascites,cancer pain,bone marrow suppression and so on.There were 23 literatures on the treatment of advanced liver cancer: there were 13 literatures focusing on pain relief(3 in grade II,3 in grade III and 7 in grade V),of which 5 / 13 mentioned the effective rate,the number of cases was 398,and the effective rate of pain relief was 78%-88.46%.One mentioned that the NRS pain score was lower than that of the control grou p,P< 0.05,and the other 7 / 13 were cases.The results reported that the pain symptoms were improved.There are 6 classical prescriptions including rhubarb,bupleurum and Pinellia ternata,3 Heshi prescriptions,bupleurum Shugan powder,Xiaoyao Powder and Jinlingzi powder;There are 8 literatures focusing on relieving ascites(1 in grade II and 7 in grade V),of which 1 / 8 mentioned the effective rate,the number of cases is 40,and the effective rate is70%,and the other 7 / 8 were cases.The results reported that the symptoms were improved,involving 3 classic prescriptions such as Pinellia ternata and cassia twigs and 4 seasonal prescriptions,including Sijunzi Decoction,Chaihu Shugan powder,Shenling Baizhu powder and Xuefu Zhuyu Decoction.There is one literature mainly for the treatment of hepatic encephalopathy,which is a grade III literature.The number of cases is 38.The cure effective rate of hepatic encephalopathy is92.1%,involving the Jingfang Dachengqi decoction.There is one literature mainly for the treatment of depression,which is a V-level literature,involving the classic formula Chaihu keel oyster decoction.The results reported that the symptoms were improved.There are 20 literatures on the treatment of embolism syndrome(grade II 20),of which 8mentioned the effective rate,the number of cases is 744,and the remission effective rate of embolism syndrome is 77.4%-91.43%.The other 12 mentioned the difference in the rating of symptom duration or symptom severity between the treatment group and the control group,P < 0.05,which is statistically significant,and the number of cases is 755.There are 7classical prescriptions and 8 seasonal prescriptions involving Chaihu and Guizhi,including Longdan Xiegan decoction,Chaihu Shugan powder,Wendan Decoction,Xiaoyao Powder.There were 38 articles on the treatment of liver function injury(37 articles in grade II and 1article in grade III),of which 17 mentioned the effective rate,the number of cases was 1227,and the effective rate of liver function injury relief was 65%-96.77%.The other 21 mentioned the difference between ALT and AST between the treatment group and the control group,P < 0.05,which was statistically significant,and the number of cases was 1565.There are 4 classical prescriptions and 17 seasonal prescriptions involving Bupleurum and rhubarb,including Shengyu decoction,Gexia Zhuyu Decoction,Huangqi Sijunzi Decoction,etc.There were 20 articles on the treatment of gastrointestinal reactions(13 articles in grade II and7 articles in grade V),of which 8 mentioned the effective rate,the number of cases was 626,and the effective rate of gastrointestinal reaction relief was 60%-90%.5 mentioned that the symptoms were improved compared with the control group,P < 0.05,the number of cases was 336,and the other 7 were cases.The results reported that the symptoms were improved.There are 5 prescriptions of rhubarb and Bupleurum and 9 prescriptions of time,including Sijunzi Decoction,Danggui Buxue Decoction,bupleurum Shugan powder,Erchen decoction.There are 20 literatures on the treatment of bone marrow suppression(grade II 20),of which 6mentioned the effective rate,the number of cases is 402,and the remission effective rate of bone marrow suppression is 60%-86%.The other 14 mentioned the difference between the treatment group and the control group in CD3,CD4,CD4 / CD8,NK and other indexes,P <0.05,which is statistically significant,and the number of cases is 1000.There are 2 rhubarb scriptures and 12 Shifang,including Xiaoyao Powder,Danggui Buxue Decoction,Shengyu decoction,etc.There are 4 literatures on the treatment of pain(2 in grade II and 2 in grade V),of which 2mentioned the effective rate.The number of cases is 115,and the effective rate of pain relief is 70.8%-93.1%.The other 2 were cases.The results reported that the symptoms were improved.There are 4 prescriptions involved,including 2 Classical Prescriptions such as Xiaochaihu Decoction and Alisma orientalis Decoction and 2 Seasonal prescriptions,including Qimai Dihuang pill and Sijunzi Decoction.There were 2 articles on the treatment of postoperative jaundice(1 article in grade II and 1article in grade V),1 article related to Jingfang Yinchenhao Decoction,the number of cases was 102,and the effective rate of jaundice recovery was 78.9%.The other one related to Jingfang Wuling powder and Yinchenhao Decoction,which were cases.The results reported that the symptoms of jaundice were improved.There are 5 literatures on diarrhea after targeted treatment(3 in grade II and 2 in grade V),of which 3 mentioned the effective rate,the number of cases was 141,the effective rate of diarrhea relief was 83.3%-93.3%,and the other 2 were cases.The results reported that the symptoms were improved.There are five prescriptions involved,including Huangqin decoction,Alisma Decoction and Wuling powder,and Fu Tu Dan and Si Junzi decoction.There were 4 literatures on skin rash after targeted treatment(2 in grade II and 2 in grade V).2 mentioned that there was a difference in the grade of adverse reactions between the treatment group and the control group,P < 0.05,which was statistically significant.The number of cases was 120,and the other 2 were cases.The results reported that the symptoms were improved.Four prescriptions are involved,including the classic prescription Sini Powder and licorice Xiexin Decoction,and the Shifang is Chaihu Shugan powder and Siwu Xiaofeng decoction.The literature on oral ulcer after targeted treatment was grade V,involving the classic prescription licorice Xiexin Decoction.It was a case,and the results reported that the symptoms were improved.The literature on the treatment of postoperative inflammatory intestinal obstruction is grade II,involving the Jingfang Dachengqi decoction.The number of cases is 200,and the cure rate of intestinal obstruction is 100%.The literature on the treatment of hypothyroidism was grade II,involving Liuwei Dihuang pill.The number of cases was 45.There was a difference in T3 and T4 between the treatment group and the control group(P < 0.05).The literature on blocking the increase of alpha fetoprotein was grade V,involving the classic prescription Zhuling decoction.It was a case,and the results reported that the symptoms were improved.The literature on the treatment of fever after radiotherapy was grade II,involving the Jingfang Xiaochaihu Decoction.The number of cases was 64,and the effective rate of fever relief was93.1%.The literature on the treatment of ascites after chemotherapy was 1 in grade V and 1 in grade II.One involved Wuling powder in Guizhi formula,which was a case.The results reported that the symptoms were improved,and one involved Danggui Buxue Decoction in Shifang,with an effective rate of 84.8% and 33 cases.2.The frequency of 108 prescriptions including the addition and subtraction of classic prescriptions and time prescriptions was counted,and the classic prescriptions or time prescriptions used more than 3 times were identified as high-frequency prescriptions.The final results showed that 18 prescriptions were high-frequency prescriptions,and the use times from high to bottom were as follows: Sijunzi Decoction(18 times),Xiaoyao powder(11times),Xiaochaihu Decoction(6 times),Shengyu Decoction(6 times),Wuling powder(5times),Chaihu Shugan powder(5 times)Dioscorea pill(4 times),Danggui Buxue Decoction(4 times),Dachaihu Decoction(3 times),Sini powder(3 times),Yinchenhao Decoction(3times),rhubarb Zhezhuang pill(3 times),Xiayuxue Decoction(3 times),Xiaochengqi Decoction(3 times),Longdan Xiegan Decoction(3 times),Baoyuan Decoction(3 times),Gexia Zhuyu Decoction(3 times)and Xuefu Zhuyu Decoction(3 times).3.There are 36 literatures(33 in grade II,1 in grade III and 2 in grade V)on the treatment of liver cancer and its complications or adverse reactions after intervention with traditional Chinese medicine,including 18 probable syndromes,including pain,fever,abdominal distension,nausea and vomiting,hiccup,lack of appetite,jaundice,ascites,thirst,constipation,diarrhea,yellow and red urine,insomnia,blood in stool,convulsions,soreness and weakness of waist and knee,spontaneous sweating and delirium.There are 27 literatures on the possibility of pain in liver cancer and its complications or adverse reactions after intervention,of which 19 traditional Chinese medicines are used,with a total frequency of 70 times.The selected drugs are mainly drugs for promoting blood circulation and removing blood stasis and regulating qi.The drugs for promoting blood circulation and removing blood stasis are used 36 times,and the drugs for regulating Qi are used 17 times.The commonly added drugs are Corydalis Corydalis,Yujin and neem.The frequency of Corydalis Corydalis Corydalis is22 times,and the frequency of Curcuma is 7 times The frequency of using neem was 7 times;There are 18 literatures on fever probability,including 19 traditional Chinese medicines used,with a total frequency of 42 times.The selected drugs are mainly antipyretic drugs,with a frequency of 32 times.The drugs often added are gypsum,gardenia,Herba Artemisiae,Radix Scutellariae,Anemarrhenae and Artemisia annua,with a frequency of 6 times for gypsum,5times for gardenia,4 times for Herba Artemisiae,4 times for Radix Scutellariae,4 times for Anemarrhenae The use frequency of Artemisia annua was 3 times;There are 14 literatures on the possibility of abdominal distension,of which 13 traditional Chinese medicines are used,with a total frequency of 37 times.The selected drugs are mainly Qi regulating drugs and dampness removing drugs.The frequency of Qi regulating drugs is 20 times,and the frequency of dampness removing drugs is 12 times.The frequently added drugs are Magnolia officinalis,cortex bovis,and Radix Aucklandiae.The frequency of Magnolia officinalis is 8times,cortex bovis is 6 times,and cortex bovis is 5 times;There are 14 literatures on the possibility of nausea and vomiting,of which 12 traditional Chinese medicines are used,with a total use frequency of 32 times.The selected drugs are mainly phlegm resolving,cough and asthma relieving drugs and surface relieving drugs.The use frequency of phlegm resolving,cough and asthma relieving drugs is 18 times,and the use frequency of surface relieving drugs is 5 times.The commonly added drugs are pinellia ternata,Zhuru,compound flowers,ginger and Amomum villosum.The use frequency of pinellia ternata,Zhuru and compound flowers is 7 times,7 times and 5 times,Ginger was used 4 times and Amomum villosum was used 3 times;There are 4 literatures on the occurrence of hiccup,of which 5 traditional Chinese medicines are used,with a total frequency of 9 times.The selected drugs are mainly phlegm resolving,cough and asthma relieving drugs and Qi regulating drugs,the frequency of phlegm resolving,cough and asthma relieving drugs is 4 times,and the frequency of Qi regulating drugs is 3 times.The frequently added drugs are: compound flower and persimmon stalk,mainly compound flower and persimmon stalk,compound flower and persimmon stalk,3 times and persimmon stalk;There were 8 literatures on the probability of anorexia,of which4 traditional Chinese medicines were used,with a total use frequency of 27 times,all of which were anti food drugs.The drugs often added were: Shenqu,malt,hawthorn and Jineijin.The use frequency of Shenqu was 8 times,malt was 7 times,hawthorn was 6 times and Jineijin was 5 times;There are 11 literatures on the possibility of jaundice,of which 7 traditional Chinese medicines are used,and the total use frequency is 20 times.The drugs are mainly diuretic and antiphlogistic drugs,and the use frequency of diuretic and antiphlogistic drugs is14 times.The drugs often added are: Herba Artemisiae and Herba Lysimachiae,the use frequency of Herba Artemisiae is 10 times,and the use frequency of Herba Lysimachiae is 4times;There are 13 literatures on the occurrence of ascites,of which 12 traditional Chinese medicines are used,with a total frequency of 38 times.The drugs mainly include diuretic and Qi regulating drugs.The frequency of diuretic and Qi regulating drugs is 18 times,and the frequency of Qi regulating drugs is 8 times.The frequently added drugs are: big belly skin,polyporus umbellatus,Alisma orientalis and plantain seeds.The frequency of big belly skin is8 times,polyporus umbellatus is 6 times and Alisma orientalis is 5 times,The use frequency of the front wheel is 4 times;There are 5 literatures on the possibility of thirst,of which 5traditional Chinese medicines are used,and the total use frequency is 11 times.The selected drugs are mainly yin tonic drugs,and the use frequency of yin tonic drugs is 10 times.The drugs often added are: Radix Ginseng and Ophiopogon japonicus,radix ginseng is used 5times,Ophiopogon japonicus is used 3 times;There are 5 literatures on the possibility of constipation,of which 5 traditional Chinese medicines are used,with a total frequency of 10 times,4 times of catharsis drugs,4 times of phlegm resolving,cough relieving and asthma drugs,and the frequently added drugs are Gualou and Yuli Ren,4 times of Gualou and 3times of Yuli Ren;There are 3 literatures on the possibility of diarrhea,of which 3 traditional Chinese medicines are used,and the total frequency of use is 5 times.The selected drugs are mainly Qi tonifying drugs and dampness removing drugs.The frequency of use of Qi tonifying drugs is 3 times,and the frequency of use of dampness removing drugs is 2 times.The frequently added drugs are: white lentil,Atractylodes macrocephala and Atractylodes macrocephala.The frequency of use of white lentil is 2 times,Atractylodes macrocephala is 2times,and Atractylodes macrocephala macrocephala is 1 time;There are 3 literatures on the possibility of yellow and red urination,of which 5 traditional Chinese medicines are used,and the total use frequency is 7 times.The selected drugs are mainly antipyretic drugs and blood cooling and hemostatic drugs,the use frequency of antipyretic drugs is 2 times,the use frequency of blood cooling and hemostatic drugs is 2 times,and the frequently added drugs are: plantain seed and white grass root,the use frequency of plantain seed is 2 times,and the use frequency of white grass root is 2 times;There are 2 literatures on the probability of insomnia,of which 5 traditional Chinese medicines are used,and the total use frequency is 6times.The selected drugs are mainly tranquilizing drugs,and the use frequency of tranquilizing drugs is 5 times.The frequently added drugs are: sour jujube kernel,and the use frequency of sour jujube kernel is 2 times;There are 4 literatures on the probability of hematochezia,of which 5 traditional Chinese medicines are used,and the total use frequency is 7 times.The selected drugs are mainly hemostatic drugs,and the use frequency of hemostatic drugs is 6 times.The drugs often added are: Festuca arundinacea root,and the use frequency of Festuca arundinacea root is 3 times;There was one literature on the possibility of convulsion,which was selected as the medicine for relieving wind and spasm,and the added drugs were antelope horn and Uncaria;There was one literature about the possibility of waist and knee soreness.Drugs for tonifying liver and kidney and strengthening muscles and bones were selected,and the added drugs were Dipsacus and mulberry parasitism;There was one literature on the possibility of spontaneous sweating.The drugs selected were astringent drugs,and the added drugs were oyster and floating wheat;There is one literature on the possibility of delirium.The drugs for calming wind and antispasmodic are selected,and the added drugs are bezoar.4.High frequency drug matching(frequency ≥ 3): in 27 literatures with probable pain,corydalis Corydalis neem,corydalis Corydalis tulip and Corydalis Corydalis Aucklandia often appear in pairs,with the frequency of 6,4 and 3 in turn.Among the 14 literatures with the probability of abdominal distension,the two kinds of Magnolia officinalis,Magnolia officinalis and Cortex Magnoliae Officinalis often appeared in pairs,and the frequency of occurrence was 4.Among the 14 literatures with probable syndrome of nausea and vomiting,pinellia ternata and Zhuru often appeared in pairs,with a frequency of 4.In 18 literatures with fever probability,gypsum Anemarrhena often appeared in pairs,with a frequency of 3.Among the 11 literatures with probable jaundice,Herba Artemisiae and Herba Lysimachiae often appeared in pairs,with a frequency of 3.Among the 5 literatures with the probability of thirst,Radix Adenophorae Ophiopogon japonicus often appeared in pairs,with the frequency of 3.Among the 5 literatures with constipation probabilities,Gualou Yuli Ren often appeared in pairs,with a frequency of 3.5.High frequency angle drugs(frequency ≥ 3): among the 8 literatures with the probability of anorexia,4 appeared the combination of Shenqu malt hawthorn;Among the 14 literatures on the possibility of abdominal distension,3 were combined with the three drugs of bark of the abdomen,Magnolia officinalis and Aucklandia;Among the 14 literatures on the possibility of nausea and vomiting,3 appeared the combination of pinellia ternata,ginger and Convolvulus.6.A total of 259 chemical targets of Dachaihu Decoction and 819 disease targets of embolism syndrome after TACE for liver cancer were collected by using the method of network pharmacology.pp I network diagram shows that AKT1,VEGFA,IL1 B,Tp53,p TGS2,MMp9,CASp3,Jun,EGF and HIF1 A are the most connected targets.Through screening the core components,quercetin,luteolin,wogonin β-The active components such as sitosterol,baicalein and kaempferol have great correlation with potential targets.The results of go analysis showed that a total of 1828 entries were obtained,which were enriched to 1714 biological processes;Enriched to 38 cell components;Totally 76 molecular functions were enriched.After 58 common targets were run in R language,a total of 156 KEGG pathways were obtained.Conclusion:1.In the treatment of liver cancer,classical prescriptions mainly composed of bupleurum,rhubarb and cassia twigs can be applied,such as Xiaochaihu Decoction and Bupleurum cassia twig dry ginger decoction;Xiayuxue Decoction,Yinchenhao Decoction,Dachengqi Decoction;Wuling powder,etc.And the prescription mainly for soothing the liver and removing dampness,such as Xiaoyao powder and Chaihu Shugan powder;Shenling Baizhu powder,Wupi drink,etc.2.In the treatment of TACE postoperative embolism syndrome,we can apply the classic prescriptions mainly composed of bupleurum,rhubarb and gypsum,for example;Dachaihu Decoction and Xiaochaihu Decoction;Rhubarb Zhezhuang pill;White ginseng soup.As well as the prescription that mainly focuses on soothing the liver and purging one by one,such as Longdan Xiegan Decoction and Chaihu Shugan powder;Gexia Zhuyu Decoction,Xuefu Zhuyu Decoction,etc.In case of liver function injury after treatment intervention,classical prescriptions mainly composed of bupleurum,rhubarb and Astragalus can be applied,such as Sini powder and Xiaochaihu Decoction;Xiaochengqi Decoction;Buzhong Yiqi Decoction,etc.And the prescriptions mainly for tonifying and soothing the liver,such as Sijunzi Decoction and Shengyu Decoction;Xiaoyao powder,etc.In case of digestive tract reaction after treatment intervention,the classic prescriptions dominated by rhubarb,bupleurum and pinellia ternata can be applied,such as rhubarb Zhezhuang pill and Xiaochengqi Decoction;Sinisan;Xiaobanxia soup,etc.And the prescription mainly composed of liver soothing,dampness removing and tonifying prescriptions,such as Chaihu Shugan powder;Zhuling decoction,Erchen decoction;Sijunzi soup,etc.In case of bone marrow suppression after treatment intervention,the classical prescriptions dominated by rhubarb can be applied,such as rhubarb Zhezhuang pill,Xiaochengqi decoction,etc.And the prescription based on tonic prescriptions,such as Sijunzi Decoction,angelica Buxue Decoction,etc.In case of pain after treatment intervention,classic prescriptions dominated by Bupleurum can be applied,such as Xiaochaihu Decoction.In the treatment of jaundice after operation,we can apply the classic prescriptions dominated by rhubarb,such as Yinchenhao Decoction.When diarrhea occurs after targeted treatment,the classic prescriptions mainly based on cassia twigs can be applied,such as Wuling powder,Zexie decoction,Huangqin Decoction and so on.When skin rash occurs after targeted treatment,Chaihu formula Sini powder,Shugan formula Chaihu Shugan powder and Siwu Xiaofeng powder can be used.3.Among the classical and current prescriptions involved in this study,Sijunzi Decoction,Shengyu decoction,angelica Buxue Decoction,Baoyuan Decoction and Dioscorea pill are often used as the basic prescriptions to replenish qi and blood,and are added or subtracted to treat Qi and blood deficiency syndrome in various complications or adverse reactions.Dachaihu Decoction and Longdan Xiegan decoction are often used in embolism syndrome.Wuling powder in Guizhi formula and Huangqin Decoction in Jingfang are often used as basic prescriptions to treat ascites,diarrhea and other complications or adverse reactions caused by abnormal body fluid metabolism.Rhubarb formula and Xie Zhushi formula can also be used as the basic formula to add or subtract the complications or adverse reactions after treatment intervention.4.When the liver cancer and its complications or adverse reactions after intervention have pain probability,the drugs selected are mainly drugs for promoting blood circulation and removing blood stasis and drugs for regulating qi,and drugs are often added;Corydalis Corydalis,tulip,neem seed,corydalis Corydalis-neem seed,corydalis Corydalis-Tulip,corydalis Corydalis-wood incense,etc.are often used in pairs to increase the efficacy;In case of fever probability,the drugs selected are mainly antipyretic drugs.The drugs often added are gypsum,gardenia,Herba Artemisiae,Radix Scutellariae,Anemarrhena asphodeloides and Artemisia annua.Gypsum Anemarrhena asphodeloides are often used in pairs to increase the efficacy;In case of probable abdominal distension,the drugs selected are mainly Qi regulating drugs and dampness removing drugs.The drugs often added are:Magnolia officinalis,Cortex Magnoliae,Cortex Magnoliae officinalis,Cortex Magnoliae officinalis and Cortex Magnoliae officinalis,which are often used in pairs to increase the efficacy,and Cortex Magnoliae officinalis and Cortex Magnoliae Officinalis are often used in combination to increase the efficacy;When there is a possibility of nausea and vomiting,the drugs selected are mainly phlegm resolving,cough relieving and asthma relieving drugs and surface relieving drugs.The drugs often added are: pinellia ternata,Zhuru,compound flowers,ginger and Amomum villosum.pinellia ternata-Zhuru is often used in pairs to increase the efficacy,and pinellia ternata-ginger-compound flowers are often used in combination to increase the efficacy;In case of possible hiccup,the drugs selected are mainly drugs for resolving phlegm,relieving cough and asthma and regulating qi.The drugs often added are:Compound flowers and persimmon stems;When the probability of anorexia occurs,the drugs selected are mainly dietetic drugs,and the drugs often added are: Shenqu,malt,hawthorn and Jineijin,and the combination of Shenqu malt Hawthorn can increase the efficacy;In case of jaundice,the main drugs are diuretic and antiphlogistic drugs.The drugs often added are:Herba Artemisiae and Herba Lysimachiae.Herba Artemisiae Lysimachiae is often used in pairs to increase the efficacy;When ascites is likely to occur,drugs such as diuretic and hygroscopic drugs and Qi regulating drugs should be selected.Drugs often added are:abdominal skin,polyporus umbellatus,Alisma orientalis and plantain seeds;When there is a possibility of thirst,the drugs selected are mainly yin tonic drugs.The drugs often added are:Radix Ginseng and Ophiopogon japonicus,and Radix Ginseng Ophiopogon japonicus is often used in pairs to increase the efficacy;When constipation occurs,the drugs selected are mainly catharsis drugs,phlegm resolving,cough relieving and asthma drugs.The drugs often added are: Gualou and rhubarb,and Gualou Yuli kernel are often used in pairs to increase the efficacy;In case of diarrhea,the drugs selected are mainly Qi tonifying drugs and dampness removing drugs.The drugs often added are: white lentil,Atractylodes macrocephala and Atractylodes macrocephala;When there is a possibility of yellow and red urine,the drugs selected are mainly heat clearing drugs and blood cooling and hemostatic drugs,and the drugs often added are: plantain seed and white grass root;When there is a probability of insomnia,the drugs selected are mainly tranquilizing drugs,and the drugs often added are: sour jujube kernel;When there is a probability of bloody stool,hemostatic drugs are the main drugs,and the drugs often added are: Festuca arundinacea root;When there is a possibility of convulsion,the drugs selected are mainly wind calming and antispasmodic drugs,and the drugs often added are: antelope horn and Uncaria;When there is a possibility of waist and knee soreness,the drugs selected are mainly drugs for tonifying the liver and kidney and strengthening muscles and bones,and the drugs often added are: Dipsacus and mulberry parasitism;When spontaneous sweating occurs,astringent drugs are the main drugs,and the drugs often added are: oyster and floating wheat;When there is a possibility of delirium,choose wind calming and antispasmodic drugs,and often add drugs: bezoar.5.Various active ingredients in Dachaihu decoction,including quercetin,luteolin,wogoninβ-Sitosterol,baicalein and kaempferol regulate AKT1,VEGFA,IL1 B,Tp53,p TGS2,MMp9,CASp3,Jun,EGF,HIF1 A and other targets,as well as tumor necrosis factor signal pathway,IL-17 signal pathway,p I3 K Akt signal pathway,p53 signal pathway,liver cancer,colorectal cancer,lung cancer,glioma and other tumor related pathways.participate in the biological processes of cytochemical stress response,lipid and atherosclerosis,oxidative stress response and so on to play a role in the treatment of embolism syndrome after TACE for liver cancer. |
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