Clinical Study On The Treatment Of Ulcerative Colitis Of Large Intestine Damp-heat Type With Acupuncture And Medicin

Purpose: By observing the changes of TCM symptoms,inflammation index(CRP,ESR)level,quality of life score,etc.in the two groups of patients with ulcerative colitis of damp-heat type of large intestine in mild and moderate active stage before and after treatment,the clinical efficacy and safety of acupuncture combined with traditional Chinese medicine in treating ulcerative colitis were clarified,and objective indexes were further provided for clinical treatment and efficacy evaluation of UC.Material and method:1.60 patients with UC of damp-heat type of large intestine in mild or moderate active stage were randomly divided into traditional Chinese medicine group and acupuncture-medicine group.2.The traditional Chinese medicine group was given Qingchang Yuyang decoction(composition: Coptis root 10 g,Milkvetch root 15 g,Amur cork-tree 15 g,Hyacinth bletilla 10 g,Garden burnet root 15 g,Debark peony root 15 g,Lightyellow sophora root 15 g,Thunberbg fritillary bulb 15 g,Cuttlebone 15 g,Sanqi 3g,Liquorice root 10g)orally and traditional Chinese Medicine decoction(composition: Coptis root 30 g,Amur cork-tree 30 g,Lightyellow sophora root 20 g,Garden burnet root 30 g,Debark peony root 30 g,Hyacinth bletilla 30 g,Liquorice root 20g)enema.3.The acupuncture-medicine group was combined with acupuncture on the basis of the traditional Chinese medicine group(acupoints: Zhongwan(RN12),Tianshu(ST25),Shangjuxu(ST37),Zusanli(ST36),Diji(SP8),Add Yinlingquan(SP9)to those with more mucus in stool,add Taichong(LR3)to those with reduced pain after defecation,add Zhonglvshu(BL29)to those with tenesmus,add Neiting(ST44)to those with Bitter taste and dry mouth and add Quchi(LI11)to those with burning pain in anus).4.After 2 weeks of treatment,TCM syndrome efficacy,the clinical efficacy,inflammatory indicators(CRP,ESR),quality of life score and safety indicators were observed before and after treatment.5.The data were collected by Excel software and analyzed by statistical software SPSS Statistics 23.0.Results:1.Therapeutic effect of TCM symptoms: the total effective rate of TCM symptoms in the acupuncture-medicine group was 96.67%,including clinical remission in 6 cases,markedly effective in 20 cases,effective in 3 cases and ineffective in 1 case;the total effective rate in the traditional Chinese medicine group was 93.33%,including 2 cases of clinical remission,15 cases of marked effect,11 cases of effective and 2 cases of ineffective.The TCM syndromes of the two groups of patients with UC were significantly improved after treatment,and the acupuncture-medicine group was superior to the traditional Chinese medicine group(P<0.05).2.Comparison of individual symptom scores:the symptoms of the two groups were significantly relieved after treatment,and the improvement of diarrhea and acute severe symptoms in the acupuncture-medicine group was better than that in the traditional Chinese medicine group on the 3rd and 14 th day(P < 0.05).The improvement of purulent and bloody stool,acute and severe stool,anal burning,dysentery and abdominal distension in the acupuncture-medicine group was better than that in the traditional Chinese medicine group.3.Among the 60 patients included in this study,31 patients were followed up for enteroscopy reexamination.According to the improved Mayo score,10 patients in the acupuncture-medicine group were completely relieved,5 patients were not completely relieved,and the clinical remission rate was 66.67%.In the traditional Chinese medicine group,4 patients were completely relieved,12 patients were not completely relieved,and the clinical remission rate was 25.00%.After inspection,the acupuncture-medicine group is superior to the traditional Chinese medicine group in the remission rate(P<0.05).4.Inflammatory indexes: there was no significant difference in ESR and CRP between the two groups before treatment,but there was significant improvement in both groups after treatment,and the acupuncture group was superior to the traditional Chinese medicine group(P<0.05).5.Quality of life: both groups can significantly improve the quality of life of UC patients(P<0.001),and the acupuncture-medicine group is better than the traditional Chinese medicine group(P<0.05).6.Safety indicators: The safety indicators(WBC,ALT,BUN,Scr)of acupuncture-medicine group and traditional Chinese medicine group before and after treatment had no statistical difference(P>0.05),and no serious adverse reactions and complications occurred in the two groups during the observation period.Conclusion: Acupuncture combined with Qingchang Yuyang decoction oral and retention enema of traditional Chinese medicine decoction in the treatment of mild to moderate active ulcerative colitis of damp-heat type of large intestine is superior to the simple traditional Chinese medicine group in improving the curative effect of TCM symptoms,inducing symptom relief and improving the quality of life,and the safety is good,so it can be used as a treatment choice for patients with UC of damp-heat type of large intestine.