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Effects Of Gamma Radiation On Brain Learning And Memory And Its Mechanism

Posted on:2013-11-25Degree:DoctorType:Dissertation
Country:ChinaCandidate:F GaoFull Text:PDF
GTID:1101330434955188Subject:Nuclear technology and applications
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With the wider use of the radiation sources and nuclear energy,modern nuclear technology has applied to almost every aspect of thesocio-economic. It has played a significant role in basic disciplines suchas physics, chemistry, biology, agriculture, medicine, aerospace and so onand has solved many problems that other means do not resolve. Nucleartechnology has produced very high economic and social benefits to thehuman society. However, with the extensive use of the radiation sourcesand nuclear energy, it brought great benefits to the mankind while it alsohas significantly increased opportunities for human exposure to thenuclear radiation, in particular long-term low-dose radiation. Therefore,human should be the maximum use of the nuclear radiation at the sametime, an in-depth study on the biological effects of the radiation, theinteraction of nuclear radiation with physical bodies and survey itsphysical, chemical, and biological mechanism.In this paper, we mainly have the experimental and theoretical studyof the effects of low-dose Gamma radiation on learning and memory inrats. The two basic content of the experimental study are as follows:(1)the damage of low-dose Gamma radiation on learning and memory abilityin rats.(2) the improvement of low-dose Gamma radiation of memoryability decline in animals due to stress-induced effect. The quantuminformation and quantum computation theory is used to study the physical mechanism of the effect of Gamma irradiation on learning andmemory ability of brain injury.137Cs used as irradiation source in the experimental research,theprinciple of radiation dose control does not damage tissues and organsand do not affect the animal’s metabolic functions. The irradiation way isexternal irradiation. We explored effects of Gamma radiation on learningand memory of the rats brain with an animal model of object recognitionmemory that has been widely used as a model of memory impairment,and the description of animal’s memory ability with coefficient ofidentification. Methods:SD male rats weighed180~220g were randomlydivided into experiment and control groups, each group of (n=8~12).The experimental results:the average coefficient of identification ofexperiment group is(-0.0408)and control group is0.3945when theaverage of whole-body rat absorbed doses for8.14μ Gy;the averagecoefficient of identification of experiment group is(-0.1031)and controlgroup is0.3605when the average of whole-body rat absorbed doses for8.12μ Gy;the results showed that the low dose γ-ray can impair thelearning-memory in rats. The average coefficient of identification ofexperiment group is0.4416and control group is0.1849when the averagehippocampus absorbed doses for rats irradiated with4.90μG y, the resultsindicate that the suitable dose γ-ray can be improved by stress to thememory capacity. To explain theoretically γ irradiation impaired on large ratslearning-memory, the system dynamics equation is established and solvedbasis quantum information and quantum computation theory, and weillustrated the physical mechanism of this damage by coherence of MTquantum state. Therefore, through analysis on comparing with thenon-ionization radiation, a new interaction mechanism of ionizingradiation and organism is further confirmed.The results of this research will not only enbale people to more fullyunderstand the biological effects of ionizing and interaction mechanismof interaction ionizing radiation with cerebral neurous system, and moreeffective use of radiation for people providing a theoretical and practicalguide to treatment of diseases of the nervous system.
Keywords/Search Tags:low-dose, Gamma radiation, learning and memory, quantuminformation
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