| The volume of trade of Chinese drug (TCD) is approximately 160 billion US dollars in theinternational market, 3 percent of them belongs to China. Especially for the patent medicinemarket, China only takes up 21.4 percent. This means that the most Chinese drugs are made byother countries, in case that China has rich plants for medicines and is known well as the cradleof Chinese drug. The way is only modernization of Chinese drug. The extraction is the modern types of TCD, it has wide international market space, so theindustrialization extraction has a vast development prospect. The extraction, separation andpurification are the key basic technologies of Chinese drug modernization and play a veryimportant role in the . Because the essentialcomponents or the cluster of essential components must be attained, the modernization ofChinese drug may be carried out. The extraction technologies of herbs include of soakage, decoction, reflux, and distillation. Ifheated many essential components may be denaturalization, reaction, volatilization and loss,the efficacy of a drug will be lower. The high pressure extracting technology (HPET) is a new way for realizing themodernization of Chinese drug. The technology is firstly used to extract the essentialcomponents of herbs in this paper. Several key technical problems oh the technology arestudied as follows: 1. HPET is use to extract the essential components first time. This is a new exploration andprobing to extract the essential components from herbs. The effect factors of HPET areanalyzed with the korean epimedium produced at Chang Bai mountains in detail. The basicparameters' ranges of HPET to extract the epimeddium flavonoid are as following: pressure200~600MPa, holding pressure time 5~10min. These results not only provide experimental andtheoretical basis more for extracting the essential components of epimedium leaf by HPET, butalso good experience for extracting the other different kinds of herbs and parts of a plant(including root, stem, leaf, flower and fruit). 2. The process parameters of HPET for the epimedium are optimized by using the trialoptimization design way, the mathematic model is set up, and the optimum process parametersare as following: pressure 400MPa, holding pressure time 5 min, 30 alcohol, compoundingratio 1 50 (raw material: solvent). In this condition, the is 8.55%. While the alcoholconcentration lowers than the extraction solution is no chlorophyll. So the purificationand separation of the solution are not only very convenient and rapid, but also sparing a lot of 124raw materials, time and equipments. We come to a conclusion on the HPET as follows:extracting at normal temperature, the essential components without loss and denaturalization,time of extraction being short, the achievable yield being high, purification and separationbeing easy, economizing on energy and without contamination. HPET is better than thetraditional technologies and the " green" extracting technologies such as supercritical CO2extraction and ultrahigh pressure homogenization extraction developed at home and abroad atpresent. 3.The extracting method, process, characteristics, principles, application and social andeconomic benefits among HPET, heat-reflux, super critical and ultrasonic technologies arecompared and analyzed systematically, which comes to the following conclusion. HPET hasthe highest achievable yield for the essential components extraction of Epimedium on thecondition of without chlorophyll in the extracted solution. The achievable yield of HPET is1.56 times of reflux, 1.99 times of supercritical CO2. The extraction time of HOET is up 1/30of reflux. The dosage of used solvent is the least, only 1/2 of the reflux and heat soakage.HPET can be operated at normal temperature, without heating. The used energy is also thelowest, only 1 of the re...
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