Synthesis, Characterization, Antibacterial And Antitumor Activities Of Metal Complexes Containing Quinolones

Quinolones is an exceedingly interesting class of antibacterial drugs because of their excellent activity, wide spectrum and low toxicity. It is known that some drugs act via chelation or by inhibiting metalloenzymes, but for most of the drugs that could act as potential ligands little is known about how metal binding influences their activity. Ciprofloxacin, norfloxacin and ofloxacin are considered the best of quinolone family of the third generation. The coordination chemistry of these drugs with metal ions, interaction model between drug and DNA, antibacterial and antitumor activities of quinolone complex are of considerable interest.Firstly, metal ions play a vital role in a vast number of widely differing biological process. The interaction of these ions with drugs administered for therapeutic reasons is a subject of considerable interest. It is known that some rare earth ions have antitumor activity. The preparations and some properties are reported of forty-five quinolone complexes with transition series metal ions and rare earth ions. The complexes have been characterized by elemental analyses, molar conductance, FT-IR, EPR, and so on. The crystal structure of metal ionic quinolone compound, (HCPFX)₂ [CdCl₄]·3H₂O, has been determined, intramolecular hydrogen bond effect and synthesis condition were discussed.Secondly, the synthesis and characterization of six mixed ligand complexes of copper with quinolones and N-N donors are presented as following.1. Norfloxacin complexesCrystal structures of [Cu(NFLX)(phen)(H₂O)]NO₃ ? 3H₂O(I) and [Cu(NFLX)(bipy) NO₃] ? 2H₂O(II) have been determined by X-ray diffraction method. Hydrogen bond effect (strong and weak effect), aromatic ring stacking and FT-IR of the complexes are discussed. EPR studies have been made on complex I in various states (polycrystalline powder or solution) and in various solvents at room temperature and 77K, the spectral parameters, the bonding characterization and stability of the complex I were discussed, the results show that the in-plane σ-bond and in-plane Ï€ -bond in the complex play an important role.2. Ciprofloxacin complexesCrystal structures of {[Cu(L)(bipy)](C₂H₅OH)(5H₂O)}_n(III), [Cu(cip)(bpy)Cl] ? 2H₂O(IV), [Cu₂(cfc)₂(bpy)₂(pip)] ? 6H₂O(V) and [Cu₂(cfc)₂(phen)₂(pip)] ? 6H₂O (VI) have been...