Study On The Supramolecular Character Of Pyridine Carboxamide Complex And The Bioactivity Of Multi(5-florouracil)

The rational design and preparation of supramolecular coordination with tailored structures and special functions is one of the main focuses in current crystal engineering. In this thesis, a series of new pyridine carboxamide ligands have been designed and prepared. By these ligands, a total of 17 novel metal complexes have been synthesized by the self-assembly with transition metals through the coordination combining with intermolecular hydrogen-bonding interactions. All of them have been structurally determined by IR, elemental analyses and X-ray crystallography. The factors governing the framework formations of these complexes have been discussed. This thesis includes five parts as follows.1. The backgrounds and some relative concepts of this work are briefly introduced. The coordination chemistry of pyridine carboxamide ligands is concisely reviewed.2. A total of twenty-four new pyridine carboxamide ligands have been synthesized and structurally characterized. Among them, four representative ligands have been determined by X-ray crystallography, and their self-assemblies into supramolecular networks through intermolecular hydrogen bonds in solid state have also been discussed.3. By using the heterocycliethioether-containing pyridine carboxamide ligands, we have successfully synthesized ten complexes with diverse supramolecular network structures by the self-assembly with different transition metals through the coordination combining with the intermolecular hydrogen-bonding interactions. The coordination features of this kind of ligands are discussed using quantum chmeistry calculation, and find that the coordination behaviors of these ligands are the corporate result of the electronic effect and the hindrance effect. It is the first time to obtain a novel cyanide-bridging multinuclear CuI coordination polymer by the reaction of one of these ligands with CuI in a CH3CN/EtOH system.4. By using the bispyridine carboxamide ligands, we have successfully synthesized seven complexes with diverse supramolecular network structures by the self-assembly with different transition metals through the coordination and the intermolecular hydrogen-bonding interactions. The coordination features of the ligands and the factors governing the network structure are discussed5. Eight novel multi(5-florouracil) derivatives have been synthesized by the reactions of 5-floroureacil with varied bromides. All of them have been structurally determined by IR, 1H NMR, 13C NMR and elemental analyses. It is the first time to determine the crystal structure of a tri(5-florouracil) derivative, which reveals the structure is a 3D supramolecular network. The antitumor biological activities of these 5-florouracil derivatives have been investigated.