Studies On Therapeutic Basis Of Maxingshigan Decoction And Development Of New Drug

Maxingshigan Decoction was recorded in《Treatise on Febrile Diseases》by Zhang zhong-jing in Han Dynasty, which was composed of ephedra,bitter apricot kernel,prepared licorice root and gypsum. It had the effects of clearing lung-heat and relieving cough and ashma and was often used to treat acute and chronic bronchitis,bronchial asthma and so on. In order to clarify the science and mechanism of prescription compatibility ,to give scientific evidence for exploiting new-styly product of Chinese traditional medicine,the compatible regulation and therapeutic basis were researched.After different compatibility of four drugs,the contents of ephedrine,amygdalin and glycyrrhizinic acid were reduced,and the content of calcium sulphate was slightly increased in decoction compared with every single decoction.Glycyrrhetic acid was not detected in the Maxingshigan Decoction,licorice root decoction and component compatibility of effective substance , this showed that glycyrrhizic acid was decomposed to generate glycyrrhetic acid by gastric acid in the stomach orβ-glucuronidase in the liver ,which contributed to detoxication,anti-inflammatory and preventing cough.The experiment ofβ2 agonist screening showed that compatibilities with ephedra had the activity of relieving asthma. This suggested that the mechanism of alleviating asthma was that when drugs were combined with the active part ofβ2 receptor ,the conformation of receptor was changed and receptor was activated,spasm of bronchial smooth muscle was alleviated,of which relieved edema of air passage,restrained inflammatory cell and so on,these would contribute to pursiness. The antiasthmatic experiments of panting guinea pigs indicated that the original prescription and Chaifang V had significance compare with control group .Pseudoephedrine and licoflavone might play synergetic effect in antiasthmatic mechnism by the analysis of HPLC. The original prescription and Chaifang V had obvious effects of relieving cough and eliminating phlegm,but hadnot conspicuous inhibition on tumour cell.In view of clinical medication property of Maxingshigana decoction,we developed it to dispensing granule which met"planning Treatment according to Diagnosis"needs and is easy to take and carry about.we optimized the extraction technology and establish the quality standard of dispensing granule.Effective groups was obtained by optimizing the extraction technology, we exploited new-style product of Chinese traditional medicine,"chuankening dropping pills".we optimized the preparation technology and set up the quality standard of dropping pills.