Cloning And Characterization Of Porcine Resistin, Adiponectin And Adiponectin Receptors Genes

Adipose tissue is not only an energy storage reservoir but also an important endocrine organ in which the metabolism is very active and the function is very complex. It can secrete a number of adipocytokines, such as TNFα, Leptin, IL-6, Adiponectin, Resistin etc. These adipocytokines can mediate the functions of many organs through autocrine/paracrine, especially regulating insulin resistance and glucose metabolic disorder linking to obesty. The insulin resistance is namely the attenuation of the insulin physiological functions. It is the major defection of type 2 diabetes and it is closely correlated to obesity.Resistin and adiponectin are newly discovered hormones specially secreted from adipocytes. Resistin is an important linkage between obesity and insulin resistance. The further investigation of resistin will have significance in directing the prevention, detection and treatment of type 2 diabetes. Adiponectin circulates in blood in multiples such as trimers, hexamers and a high molecular mass species. The globular adiponectin exists independently in vivo and has the similar functions to the full-length adiponectin. Adiponectin can stimulate the fatty acid oxidation in skeletal muscle, decrease plasma triglyceride, and improve glucose metabolism by...