Clinical Observation On Treatment Of Malignant Tumor Associated Insomnia By

Cancer is one of the most serious global health threats. Sleep quality as an important factor influencing quality of life. Insomnia associated with cancer seriously affects the quality of life of cancer patients, and even accelerates tumor progression. For these reasons, and to improve quality of life, cancer patients should seek and be offered treatment for insomnia.According to the syndrome differ classification of traditional Chinese medicine, the main pathogenesis of insomnia associated with cancerwas disharmony between the heart and kidney. Based on TCM theory and clinical practice, Kong Sheng Zhen Zhong Dan(KSZZD), a classic formula, function as restoring normal coordination between the heart and the kidney.and nourishing yin and tranquilizing the mind. In this study, the therapeutic effect on insomnia associated with cancer withKSZZDwas evaluated by randomized controlled clinical trial.Objective:To observe and evaluate the therapeutic effect on insomnia associated with cancer diagnosed disharmony between the heart and kidney with KSZZD evaluated by randomized controlled clinical trial.It will be significant to clinic practice that the classic formula of KSZZD application therapeutic effect researching by clinical trial and the further analysis of treatment’s principal.Methods:66patients with malignant tumor were collected in Dongzhimen hospital of Beijing university of Chinese medicine.6patients with malignant tumor missed. The patients were randomly divided into treatment group and control group according to their visiting sequence.Control group(n=30)was treated by conventional support. Treatment group(n=30) was treated by oral administration with one bag of KSZZD twice a day for28days continuously as one course. The influence of a course of medical treatment with KSZZD on patients were respectively studied at14, and28days, using Pittsburgh sleep quality index scale (PSQI), case watch list (CRF) and quality of sleep.The result were statistically computed with statistic SPSS18.0package.Results:There were no significant differences in the baseline level between two groups (age, sex, the treatment of disease, course of the disease)(P>0.05).Compared clinical curative effect after treatment, we analyzed the score of PSQI, TCM syndrome score.①Quality of sleep: There were significant differences in PSQI score between control group and treatment group after treatment(P<0.05). These results showed that applying KSZZD could effectively improve the sleep quality of patients and the clinical curative efficacy. There were significant differences in PSQI score between before and after treatment in control group (P<0.05). These results suggested that the sleep quality could get worse without KSZZD intervention.②Traditional Chinese medicine syndrome:Treatment group is better than control group, comparing the overall curative effect evaluation between control group and treatment group. The therapeutic effect of28days is better than14days. The syndrome of annoying, palpitation, insomnia, dizziness tinnitus, lumbar debility, dry mouth pharynx dry, tongue and pulse condition were detected after14days treatment. as compared with pre-treatment, only syndromes of tongue and pulse condition had significant difference(P<0.05).The syndromes of annoying, heart palpitations, insomnia, dizziness, tinnitus, dry mouth pharynx dry, tongue, pulse condition effect had significant difference(P<0.05) after28days treatment. Only syndromes of lumbar debility compared with before the treatment had no statistical significance(P>0.05). Compared with14days, the syndromes of dizziness, tinnitus, insomnia, tongue and pulse condition, had significant differences after28days(P<0.05), but the syndromes of palpitations upset, lumbar debility, dry mouth symptoms, had no statistical significance after28days(P>0.05). It showed that each therapeutic effect was associated with course of treatment, and the therapeutic effect of28days is better than14days.Conclusion:1.KSZZD can improve sleep quality of insomnia associated with cancer diagnosed disharmony between the heart and kidney. In patients of KSZZD group, symptom of dreaminess, dizziness, tinnitus, insomnia, tongue and pulse condition alleviated more quickly,phenomena of palpitations upset, lumbar debility, and dry throat were fewer.2. Because of the observation time is short, the long-term curative effect need to be followed up.