| Effects of bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure:An echocardiographic study of left ventricular functionObjectives The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. The aim of this study is to evaluate the effectiveness of isolated coronary artery bypass graft combined with bone marrow mononuclear cells (BMMNC) delivered through graft vessels to improve left ventricular function of patients with previous myocardial infarction and chronic heart failure using echocardiography.Methods 42 patients with previous myocardial infarction and chronic heart failure were randomly allocated to one of the two groups:CABG only (18 in CABG group), or CABG with BMMNC transplantation (24 in CABG+BMMNC group). Echocardiographic parameters of systolic function were measured on B-mode imaging, tissue Doppler imaging,2D strain imaging, and 8 parameters were measured totally. Echocardiographic parameters of diastolic function were measured on pulsed-wave Doppler imaging, tissue Doppler imaging and 2D strain rate imaging,17 parameters were measured totally.Results Postoperative LVEF vs. preoperative LVEF were 49.083 ± 1.914% vs.36.042 ± 1.185% (P<0.05) in CABG+BMMMNC group and 41.389 ± 2.210% vs.34.667± 1.369% (P<0.05) in CABG group, GLS were -12.542±0.512% vs. -7.083±0.583% (P<0.05) in CABG+BMMMNC group and -9.278±0.591% vs. -7.000±0.673% (P<0.05) in CABG group, mLsrl were -0.108±0.018s-1 vs. -0.039±0.017s-1 (P<0.05) in CABG+BMMMNC group and -0.048±0.021s-1 vs.0.004±0.020s-1 (P<0.05) in CABG group, mLsr2 were -0.05±0.013s-1 vs. -0.009±0.015s1 (P<0.05) in CABG+BMMMNC group and 0.004±0.015s-1 vs.0.024±0.017s-1 (P<0.05) in CABG group and Aal were 7.303±0.479cm/s vs.5.131±0.381cm/s (P<0.05) in CABG+BMMMNC group and 7.908±0.553cm/s vs.6.764±0.440cm/s (P<0.05) in CABG group. Parameters above were significantly improved postoperatively in both groups. The degree of the improvement was significantly different between the two groups with the CABG+BMMNC group improved more versus the group of CABG only (P<0.05).Conclusions The improvement of left ventricular function in CABG+BMMNC group is better than CABG group.2D strain and strain rate imaging is a more sensitive tool to evaluate left ventricular function.Effects of bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure:An echocardiographic study of left atrium functionObjectives The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. The aim of this study was to evaluate the effectiveness of isolated coronary artery bypass graft combined with bone marrow mononuclear cells (BMMNC) delivered through the graft vessels to improve left atrium function of patients with previous myocardial infarction and chronic heart failure using echocardiography.Methods 42 patients with previous myocardial infarction and chronic heart failure were randomly allocated to one of the two groups:CABG only (18 in CABG group) or CABG with BMMNC transplantation (24 in CABG+BMMNC group). Echocardiographic parameters were measured on 2D imaging,3D imaging,2D strain and strain rate imaging, 8 parameters were measured totally.Results Postoperative LAGS vs. Preoperative LAGS were 24.875±1.588% vs.14.250± 1.281% (P<0.05) in CABG+BMMMNC group and 17.556±1.834% vs.13.111± 1.479% (P<0.05) in CABG group, LVEF were 49.083±1.914% vs.36.042±1.185% (P<0.05) in CABG+BMMMNC group and 41.389±2.210% vs.34.667±1.369% (P<0.05) in CABG group and LAV were 15.651±0.631ml vs.23.894±0.831ml (P<0.05) in CABG+BMMMNC group and 21.429±0.707ml vs.22.379±0.959ml (P<0.05) in CABG group. LAGS, LVEF and LAV were significantly improved postoperatively in both groups. The degree of the improvement was significantly different between the two groups with the CABG+BMMNC group improved more versus the group of CABG only (P<0.05). Post-operative LVEDV and LVESV were significantly improved compared with those obtained prior to operation in CABG+BMMNC group (P<0.05).Conclusions The improvement of left atrium function in CABG+BMMNC group is better than CABG group.2D strain imaging is a more sensitive tool to evaluate left atrium function.Effects of bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure:An echocardiographic study of left ventricular remodelingObjectives The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. The aim of this study was to evaluate the effectiveness of isolated coronary artery bypass graft combined with bone marrow mononuclear cells (BMMNC) delivered through graft vessels to improve left ventricular remodeling of patients with previous myocardial infarction and chronic heart failure using echocardiography.Methods 42 patients with previous myocardial infarction and chronic heart failure were randomly allocated to one of the two groups:CABG only (18 in CABG group), or CABG with BMMNC transplantation (24 in CABG+BMMNC group). Echocardiographic parameters were measured on B-mode imaging,3D imaging and color flow imaging,9 parameters were measured totally.Results Post-operative LVEDD, LVESD, LVEDV, LVESV, LVEDVI, LVESVI, LV-mass and LV-massI were significantly improved compared with those obtained prior to operation in CABG+BMMNC group (P<0.05). The improvements were indicated by the decreased post-operative LVEDD, LVESD, LVEDV, LVESV, LVEDVI, LVESVI, LV-mass and LV-massI in CABG+BMMNC group. Post-operative LVEDD, LVESD, LVEDV, LVESV, LVEDVI, LVESVI, LV-mass and LV-massI were not significantly different from those prior to operation in CABG group (P>0.05). Postoperative MR score was not significantly different from those prior to operation in both groups (P>0.05).Conclusions The improvement of left ventricular remodeling in CABG+BMMNC group is better than CABG group. Echocardiography is a sensitive tool to evaluate left ventricular remodeling.Effects of bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure:An echocardiographic study of left ventricular asynchronyObjectives The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. The aim of this study was to evaluate the effectiveness of isolated coronary artery bypass graft combined with bone marrow mononuclear cells (BMMNC) delivered through graft vessels to improve left ventricular asynchrony of patients with previous myocardial infarction and chronic heart failure using echocardiography.Methods 42 patients with previous myocardial infarction and chronic heart failure were randomly allocated to one of the two groups:CABG only (18 in CABG group), or CABG with BMMNC transplantation (24 in CABG+BMMNC group). Three echocardiographic parameters evaluating left ventricular asynchrony were measured on 2D strain imaging.Results The effective rate of improvement to LV asynchrony of RSTb was significantly higher in CABG+BMMNC group versus CABG group (91.7% vs.50%, P<0.05), RSTm (78.6% vs.35.7%, P<0.05) and RSTa (92.3% vs.50%, P<0.05). The deterioration rate of LV synchrony of RSTb was significantly lower in CABG+BMMNC group versus CABG group (8.3% vs.70%, P<0.05) and RSTm (0 vs.50%, P<0.05). But the deterioration rate of LV synchrony of RSTa was not significantly lower in CABG+BMMNC group versus CABG group (18.2% vs.37.5%, P>0.05).Conclusions The improvement of left ventricular asynchrony in CABG+BMMNC group is better than CABG group.2D strain imaging is a more sensitive tool to evaluate left ventricular asynchrony.
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