Expression Of PRR11 In Gastrointestinal Tumors And Its Mechanism In Cholangiocarcinoma

Cholangiocarcinoma is a highly aggressive tumor of gastrointestinal cancers. According to the location, extrahepatic cholangiocarcinoma has three types: upper, middle, and lower cholangiocarcinoma. Among these three types, upper(hilar) cholangiocarcinoma occurs most, about 60-70%. It is not detectable for most patients with cholangiocarcinoma, since most patients were diagnosed at late stage when they have symptoms. Therefore, the chance of cure is limited. The incidence of hilar cholangiocarcinoma is increasing in the past decades. It is essential to investigate the underlying mechanisms of hilar cholangiocarcinoma, to search reliable biomarkers for surveillance and prognosis, and to find possible therapeutic targets. Recently, a novel candidate gene. PRR11, was found to be activated in various tumors. However, its value in hilar cholangiocarcinoma was rarely investigated. In present study, we detected PRR11 expression in human gastrointestinal tumors and analyzed its correlations with patients’ outcome. Next, we silenced PRR11 expression and observed the biological behavior of QBC939 cells after PRR11-knock-down. Finally, we tried to find PRR11-possible targets using cDNA microarray. Through this study, we confirmed the possible role of PRR11 in hilar cholangiocarcinoma and its underlying mechanisms promoting the progression of hilar cholangiocarcinoma.