| colon and rectum after surgery.Mortality of gastric carcinoma was the second highest in all kinds of malignant tumor,and its morbidity and mortality were higher in our country too,which have no declined trend. It becomes most pressing question that we find an effective cure method which can prolong survival time , improve the quality of life, and decrease the mortality. Now, the main treat methods of gastric carcinoma are surgery, chemotherapy and radiotherapy, whose effects are not very well because recurrence rate and metastasis rate are high and the quality of life is low. So turner researchers try to treat it with traditional Chinese medicine by single formula, experimental formula and Bianzhenglunzhi separately or combined with surgery, chemotherapy and radiotherapy, and prove their effects, find their mechinism in order to produce new dosage form whose dose is little and effect is well.Based on histology, biological behavior and epidemiological character, Lauren divided gastric carcinoma into intestinal type and diffuse type .The former was definited to be a process from atrophicans gastriti ?intestinal metaplasia ?allotypic hyperplasia, grade I , II, III,gastric carcinoma. Investigation in Linqu county of Shangdong province showed morbidity in diseases of chronic mucous were rather higher in area where incidence of gastric carcinoma is high,which might be the main factor of high gastric carcinoma incidence, moreover, this investigation showed there was family clusterimg of gastric carcinoma in part of families in this area, which3indicated incidence and development of gastric carcinoma were a gradually changed process with many factors and phases which was effected by hereditary factors and might be include comprehesive molecular pathological machinism.Recent studies indicated that many diseases related to gene chages in cell, so separation, cloning and localization of medicine-sensitive genes is base of finding radical machinism and exploiting new preventing and treating method. Human chromosome DNA is made up with 3X10"base pairs, included 100,000 genes in which there are more than 10,000 genes were cloned and located. Only 15% genes of human cell are open which can express functional protein. The others are rest and no function, but can effect when the condition out or in body change. Human gene expressional information bank includes about 15,000 different mRNA sequences. Low mRNAdess than 0. 5% total mRNA, also called rare mRNA) is about 30%of total mRNA. Rest gene and rare gene decelerate cloning new gene and studing gene function.Traditional Chinese medicine is attented for its low toxicity and effeciency along with coming of entering WTO, so deep, impersonal and systemic basal study on traditional Chinese medicine can accelerate process of its being accepted and lay a foundation for exploiting new medicine. Piwei institute of Guangzhou TCM university have researched on effect of preventing and curing gastric carcinoma with Liandaipian and its main elementæ¡žerberine. Some results showed Berberine decreased prolif ication and induced apoptosis of human gastric carcinoma cell line BGC823 and MGC803.We started primary clinical observation on effect of Liandaipian on therapy gastric carcinoma and colon and rectum carcinoma after surgery and separated target genes of Berberine acting on BGC823 in order to establish base for exploiting pharmacological machinism of Liandaipian. Results showed:1. Liandaipian improved evidently patient's symptoms and signs, especially those companied with heat, whose effective rate was90%. Otherwise, it improved Quality of Life in 10 patients with gastric carcinoma after surgery.2. We determined tumor markers in patient's serum before and after curing with Liandaipian.The results showed that CEA positive rate was 28. 75%, so CEA couldn't be used to investigate Liandaipian's clinical effect ;CA19~9 positive rate was higher than that of CEA, but there wasn't difference between before and after therapy with Liandaipian. Positive rate was...
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