| 一 Literature researchPrimary liver carcinoma ( PLC ) is a common malignant tumor in digestive tract Prognosis of PLC is disappointing that without an initiative treatment patient with PLC will expect to only survive 4 months or so between the detection of the symptoms and his death. [11]. China is among the highest incidence region of PLC, which is showed by the data from the Public Health Ministry in 1995 that PLC stands 44/100,000 of fatality rate taking the second place among all the fatal malignant tumors.The traditional Chinese medicine has long been engaging in vast researches on the diagnosis, pathogenesis and etiology, differentiation and treatment. Although there was no name as PLC in the ancient literatures of T. C. M, we can still detect the trace of it in the comments of Ganji (Liver stagnation), Zhengjia and Jiju (abdominal mass), Guzhang (cirrhosis ascites), Huangdan or pihuang (jaundice) and so on. Traditional Chinese medicine associates liver with the Foot Jueyin Channel, and the superficial connection with gall bladder. The occurrence of PLC is implicated to the reception of damp-heat evil toxin or the long-term irregular and uncontrolled eating habit, alcohol drinking, mental depression causing the liver Qi stagnation and secondarily blood stasis that will finally turn into abdominal mass as a result of disturbed Yin-Yang balance. The PLC in our country is generally related to the following major 4 factors: 1. Infection of hepatitis virus: 90% of the PLC patients from our country has a background of HBV infection and 10-30% with HCV infection. 2. the aflatoxin ingestion. 3. The contamination of drinking water in the remote country areas: such as chlorillin, the liver carcinoma inducer. 4. Other factors including alcohol, cigarette, and inheritage.An early surgery being still the best treatment program, PLC however is liable to be complicated by an early intrahepatic metastasis and severe cirrhosis so that most of the patients has missed their right time for surgery when diagnosed. In the recent decade, researchers from home and abroad haven't stopped their steps in the exploration of new non-surgery therapy for PLC. A variety of therapies have been employed in treating the metaphase and late PLC including TACE, radiotherapy, immunotherapy, biological therapy as well as traditional Chinese medicine, but none of them can promise a satisfactory long-term effect. Since various methods have their own advantages and disadvantages, it is advisable to combine them for the sake of remedying the defects, promoting effect and reducing toxicity. Therefore the comprehesnive multi-therapy provides higher possibility to improve the long-term effect in the treatment of metaphase and late PLC. Unfortunately, there isn't yet any objective and full-scale report on the effect of the comprehesnive PLC treatment in which T. C. M therapy plays the major part. As far as the effect evaluation is concerned, the current different clinical reports differ greatly mainly as a result of the fact that different researchers place different attention to different associated factors and the different state that the objective presents. The recent finding indicates: dozens items from 3 major domain of patient's state, feature of the tumor, therapeutic means are topping the list of the closest influential factors on PLC. As it is hard to exercise the conventional complete random control in clinical practice, the COX Proportional Hazard Model is widely applied among oversea researchers in the assessment of various factors associated with PLC prognosis. At home there are already some research workers to have employed this method on the analysis of PLC prognosis related factors and achieved great success. But we haven't got the chance to see the relevant literature on the T. C. M research on PLC treatment.-. Clinical study1. Objective:To observe and compare the therapeutic effects of the complex T. C. M-dominated therapy of. Medium-stage or late-stage PLC, and analyse the prognosis factors,. And to find the best...
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