| Banxiaxiexin decoction (BD), which has harmony-effect, is one of the classical prescriptions being widely used in clinic, especially in the treatment of digestive system disease. The pungent tasted pinellia, dried ginger, bitter tasted coptis, scutellariac, and sweet tasted asiabell, Chinese date, licorice composes it.Epigastric fullness is the major syndrome that is fitted BD; it is caused by the disorder of stomach movement. Aimed at the proper syndromes of BD, the stuff of this topic have done series of studies include the primary researches of the regulating effects of BD on gastrointestinal tract. The results show that the syndrome, which fitted BD, has great relativity with the reduced power of the stomach and intestine.Currently researches show that the constriction of gastric antrum disappeared when the slow wave out of gear, and interstitial cell of Cajal (ICC) plays a very important role in the process of Gastrointestinal dynamic adjustment. So, we suspected that there might be a closed relationship between the forming of the syndrome of epigastric fullness and the disorder of gastric rhythm mediated by ICC.Based on the knowledge we just mentioned above, we carried out the study on BD regulating gastric electric rhythm by divided design. The paper conclude three parts:In the first part, we reviewed the literatures of clinical and experimental studies on BD, and relative researches on Gastric Dysrhythmia Syndrome (GDS) and ICC.BD widely is used in clinic to treat many diseases of human (especially digestive system diseases). Experimental researches covered many sectors, such as mechanism of the compatibility, toxicological studies, etc. And a great deal of achievements has been gained.In semiology, epigastric fullness is very similar to GDS. The major symptoms of GDS include nausea, emesis, epigastric pain, anorexia, etc. All the symptoms mentioned above are familiar in many gastric functional diseases. In clinic, GDS can be divided into three kinds.ICC, the pacemaker of Gastrointestinal tract, which can promote the spread of electric activity, plays a very important role in the process of Gastrointestinal dynamic adjustment, has closed relationship with many gastric functional diseases. So, to study ICC is very important in understanding the mechanism of BD regulating gastrointestinal movement correctly.In the second part, we discussed Qi-theory, Jingfangfangyuan (the minimal unit of Zhangzhongjing's prescription), prescription & syndrome of BD. In short, Qi-theory is rooted in Chinese ancient philosophy and the forming of syndrome fitted BD has closed relativity with Qi in the TCM. The three groups of herbs, which composed BD, can be considered as three Jingfangfangyuan. There are related descriptions on the prescription & syndrome of BD in classical medical works, such as The Yellow Emperor's Canon of Internal Medicine, The legendary god of farming's Canon of materia medica, etc.In the third part, we combined modern mathematical statistic methods and recipe evolvement rule , adopted 23 factorial experimental design , divided BD into three single-tasted drug groups (the group containing herbs pungent in flavor, the group containing herbs bitter in flavor, the group containing herbs sweet in flavor), chose animal model of gastric electric rhythm disorder, observed the effect of BD and each decomposed group (BD&EDG) in regulating animal model's coefficient of variation of slow wave frequency of gastric electric rhythm, the content of c-kit＾│ ICC in stomach myenteric nerve plexus, the mRNA expression lever of c-kit and SCF gene in omni-wall of stomach, the lever of serum SCF. The results of this study are as follows:BD&EDG all have effects on rectifying the disorder of gastric electric rhythm, regulating c-kit＾│ ICC content in stomach myenteric nerve plexus, suppressing c-kit and SCF gene expression in omni-wall of stomach to various degrees. And there are significant difference between the treatment groups and the model group. Among all the treatment groups,...
|
PDF Full Text Request