| Banxiaxiexin Tang, which is composed of pungent tasted pinellia, dried ginger,bitter tasted coptis, scutellariac and sweet tasted asiabell, Chinese date and licorice, is arepresentative prescription being used to treat feeling of fullness in the chest and upperabdomen. It has been widely prescripted to treat various gastrointestinal abnormalityfor around 2000 years and make a name of "the representative prescription to regulatespleen and stomach by acrid drugs for dispersion and bitter drugs for purgation" foritself by its satisfying therapeutic effects. Syndrome of feeling of fullness in the chest and upper abdomen in ShanghanTheory is similar to that of gastrointestinal dynamic disorder which is characterized byfullness in the chest or abdominal distention, anorexia, abnormal feeling of overeating,nausea, vomiting, belching, acid regurgitation. Since its pathogenesis mainly isabnormal ascending and descending of visceral qi, a morbid condition due todisharmony between the function of the spleen and stomach, the according treatmentprinciple is regulating the ascending and descending of the function of the spleen andstomach. Our research group has completed a series of lab work to study the regulatoryeffects of Banxiaxiexin Tang on digestive system . The results show Banxiaxiexin Tangsyndromes are closely correlated with gastrointestinal dynamic disorder, especiallygastric dysperistalsis. There is now convincing evidence, that subpopulations of ICCare gut pacemaker cells as well as key cell for mediation of gut inhibitory innervationWith our recent knowledge, that ICC are crucial in generation of slow waves and inneural transmission in the gut Prominent motility disturbances are present in e.g.inflammatory bowel disease, functional bowel disease, diverticulosis, Hirschsprung'sdisease, intestinal pseudo-obstruction or myopathies and neuropathies, and evidence ofinvolvement of ICC in such diseases is beginning to evolve. Thus we suspected theregulatory effect of Banxiaxiexin Tang on gastric dynamic disorder may be related toICC. Based on the above, we observed the regulatory effects of Banxiaxiexin Tangand its divided groups on gastric electric dysrhythmia rats. The article is composed of 3parts. In the first part, we reviewed the modern and Chinese medical researches on thegastrointestinal dynamic disorder respectively, including its conception, classification,pathogenesis and treatment, the research of animal models is also involved. In the second part, we discussed the theoretical basis, formation and applicationrules of "acrid drugs for dispersion and bitter durgs for purgation"principle. Based on4 半夏泻心汤"辛开苦降"调节胃动力的研究the theory of ascending and descending, this principle is originated in Inner Canon ofYellow Emperor, put into practice by Zhang zhong-jing and has a great influence uponthe development of the theory and practice of TCM. In the last part, we observed the regulatory effects of Banxiaxiexin Tang ongastric electric rhythm, c-kit positive ICC content, serum SCF level and ultrastructureof ICC in gastric electric dysrhythmia rats. The results show the pungent and bitterflavor group is most effective in regulating gastric electric dysrhythmia and c-kitpositive ICC content. Of all the treatment groups, only Banxiaxiexin Tang has asignificant effect on regulating the serum SCF level, as well as affecting theultrastructure of ICC in the model animals. The results indicate that regulation of ICC may be involved in Banxiaxiexin Tangtreating feeling of fullness in the chest and upper abdomen. The pungent and bitterflavor group is supposed to play a big role in the process by contributing to regulationof ICC content and gastric electric rhythm, which may partly explains "acrid drugs fordispersion and bitter drugs for purgation can regulate the disorder of qi movement". |
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