| Research on clinical formula compatibility is an important content and advancing front field in the study of formulaeology. In the aspect, one of the major subjects is the research on prescription compatibility method and the regular pattern of combining disease diagnosis with the syndrome differentiation. In this thesis, by researching on the formula compatibility method of treating the clinical representative common disease- Essential Hypertension (EH), the proposition above has been explored to provide the foundation and a new way of thinking for clinical prescription. The thesis is divided into two parts.In the first part, the current status and shortage of the research both on clinical formula compatibility and the TCM treatment in hypertension were researched retrospectively. Clinically the syndrome differentiation types and therapeutic methods in treating EH have been found to be faulty. There is more research on syndrome differentiation and treatment of EH, but less research on evolvement of the disease process. The therapeutic method and prescription combining disease with syndrome is not easy to be formed. That makes it difficult to evaluate the effect of prescription objectively and to illustrate its mechanism. The research on preventing organ damage complication of EH is insufficient, and so on. All the above indicates the lack of the research on clinical formula compatibility that combines disease with syndrome. In the theoretic study of the second part, the theory of latent pathogenesis is taken as the important basis and supporting point of the prescription compatibility combining disease with syndrome. This research put forward for the very first time that the latent pathogenesis should include the pre-pathogenesis and post pathogenesis, which are associated directly with the current pathogenesis (apparent and concealed pathogenesis). Defining its conception and realizing its importance would be favorable to grasp the developing and evolving pattern of the disease, and also to promote the maneuverability of clinical prescription combining disease with syndrome. Conscious attention should be given to the pre-pathogenesis and post pathogenesis when prescribing herbs. So as to bring the evolvement factors of disease into the prescription therapy system, which embodies the therapy of integrating the disease diagnosis with the syndrome differentiation.On the basis of researching the cause and pathogenesis and the evolving pattern of EH in its early stage, analyzing the current clinical method and thinking in treating EH, the author put forward a hypothesis that liver fire consuming Qi is an important latent pathogenesis at the early stage of EH, clearing liver fire and supplementing Qi is animportant therapeutic method. Vascular re-modeling is the earliest manifestation of target organ damage and prognosis factor in EH. At EH's early stage, the pathogenesis of liver fire consuming Qi has a close relativity with vascular re-modeling and influencing factors in the course of disease. By researching on the antihypertensive effect and the molecular mechanism in restraining vascular re-modeling in the Spontaneous Hypertension Rat (SHR), the paper tried to prove out the deeper mechanism that makes the formula of clearing liver fire and supplementing Qi interfering with EH development and transformation.The experimental results showed that the antihypertensive formula of clearing liver fire and supplementing Qi had an obvious antihypertensive effect. Compared with Niuhuang Jiangya Wan(Niuhuang Antihypertensive Pill), its antihypertensive action was relatively weak, acting slowly but lasting longer, and had a prominent effect after taking the formula for curative courses, This formula had the effect of adjusting the ET/NO balance by boosting NO level in plasma, regulating vascular expansion and contraction to reduce vascular tension. This is probably one of the main mechanisms of the antihypertensive effect of this formula. The analyzing of taking apart the formula indicated that Huangqi had a...
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