| Tolerance is the ultimate goal in organ transplantation. To explore the optimal clinical regimen of tolerance-inducing strategy and investigate the safety and efficacy of biological products for anti-graft rejection, establishment of non-human primate renal transplantation model is a critical need, which is still unavailable in China. In present study, we successfully established cynomolgus macaque models for renal allotransplantation, following development of DRB PCR-SSP gene typing, which enables us for animal pairing. Based on this model, we also investigated the efficacy and safety of a domestically produced humanized antibody, anti-CD25 for anti-rejection. Administration of anti-CD25 alone led to significant prolongation of allograft survival. It may function by interfering in the interaction of 1L-2 and its receptor, preventing further activation of T cells that may be involved in allograft rejection otherwise. The model system we have established in this study may have a broad application for further investigating the mechanism of anti-graft rejection and tolerance induction by novel biological or chemical reagents.
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