Numerical Simulation And Experimental Study For Vascular Interventional Treatment By Bifurcated Artery

Considering the clinical problems in the current vascular interventional treatment by bifurcated artery, for the first time and by mean of numerical simulation and hydrodynamics experimental simulation, the paper tries to find out the basic fundamentals of blood flow within bifurcated artery and liquid drug transport injected into the artery in order to discover the unique local hemodynamie phenomenon and the flow mechanism of the vascular interventional treatment, which is by virtue of the studies of the distribution of pulsatile blood flow velocity, liquid drug density and the total liquid drug perfusion rate. Combining the physiological states and the anatomical parameters, the paper takes the bronchia artery infusion (BAI) of lung cancer as the prototype to carry out the study.The main works include:Illuminate the biomedical background of the study and its subjects, aims. Analyze the current development of the correlative research.On the numerical simulation model, taking the bronchia artery infusion of lung cancer as the prototype to constructure a three dimension bifurcated artery hemodynamie mathematic physical model; Selecting a periodic function as the computing entrance average velocity boundary condition of aorta, according to the normal physiological blood flow parameters.On the numerical simulation, elucidating the flow field solving methods, introducing the computational fluid dynamics (CFD) software pack - FLUENT and GAMBIT; summarizing the concrete processes of establishing the geometrical model, discreting domain, boundary conditions processing, and thedata post processing.According to the different perfusion modes, the local blood flow without the catheter intervention of the bifurcated artery is simulated numerically first, then 66 distinct perfusing modes are done with the catheter intervention. The main factors influencing the liquid drug perfusion rate, such as the relative position of the catheter spout, the liquid drug injecting angle, continuous injecting and discontinuous injecting, are studied primarily.The numerical simulation results indicate: the catheter intervention has little disturbance to the normal blood flow; during continuous injecting, the catheter spout position and the liquid drug injection angle have a strong influence on the distribution of liquid drug in the blood therefore on the perfusion rate; the optimal injection angles vary form the positions of the catheter spout.According to the reaearch results, the basic fundamentals of blood flow and liquid drug transport with the vascular interventional treatment are that the discontinuous injection phases of cardiac circle influence the liquid drug distribution and perfusion rate intensively; the optimal injection phases vary from the injection positions and liquid drug angles; around the aortic downstream near the branch artery entrance, the liquid drug perfusion rate is sensitive to the injecting angles, which is reverse around the aortic upstream.To validate the numerical simulation results, with the same prototype, a set of experimental equipment is constructed. The heart and the artery are simulated with elastic transparence silica gel. The angle of the branch artery relative to the aorta is adjustable. The liquid drug perfusion rates are measured at different injection positions, different injection angles, different injection phases of cardiac circle, injecting continuously and discontinuously. The numerical simulation results are coincident with the experimental simulation results properly, which validates the numerical simulation of the paper.In the end, several conclusions with theoretical and practical meaning are summarized, which provide basic theoretic fundamentals for practising the vascular interventional treatment by bifurcated artery efficiently and safely. Proposals forincreasing liquid drug perfusion rate are given. More research on the subject are suggested.