Simulation Experimental Study On Drug Infusion Method In Vascular Intervention Treatment

Vascular intervention treatment is an important part of intervention therapy, which is a well-advanced discipline involving clinical, medical and engineering knowledge. Interventional therapy possesses the merits of micro-wound, handiness, less risk, fast curative effect, through which new methods are applied to save those who have lost surgical hopes. Beside medicine therapy and surgical therapy, interventional therapy has become one of three main-stream methods.Interventional treatment of tumor, especially vascular intervention treatment, possesses considerable deficiency still, such as "do not care for the patient but only the symptom", despite the fact that it has predominance in chemotherapy of tumor. Exactly, the doctor sees nothing but oncosis oven or tumor cells and use chemotherapy drug to kill them in vascular interventional treatment. The result of tumor therapy must be that drug kills tumor cells, also normal cells at the same time. It leads to the finale that the patient perishes together tumor cell, or even the tragedy that the patient dies of drugs not of tumor. It was perplexing that science and technology develop fast, medical treatment level elevates continuously too, but the tumor mortality is high increasingly. This phenomenon makes us to ponder the tumor therapy actuality and the vascular intervention chemotherapy. So the researches of drug perfusion means during vascular interventional therapy were carried out as follows:Firstly, a mock circulation system for vascular interventional therapy was established, which became a platform of hemodynamics simulation experiment for the study of bronchial artery interventional (BAI) of lung cancer. The simulation hemodynamic segment designed for BAI was applied at the thoracic aorta in the mock circulation system; liquor auto-injecting device was designed accordingly. Secondly, PC-based control and measurement software module, which achieved the real-time control of both cardiac motion motor and liquid pulsating drug-injection, was programmed using Visual VC++ under Win98 system. Thirdly, a new empirical method was developed to measure the drug-perfusion rate (DPR) into branchial artery in a closed-loop circulation system, which supplies reliable guarantee for accurate measurement of DPR. Fourthly, a series of simulation experiments were carried out under varying simulation conditions; the optimum injecting modes with relatively higher DPR during vascular intervention treatment were discovered; A series of factors affecting the DPR were further analyzed and discussed, such as cardiac cycle phase, catheter-port axial position and radial position, liquid ejecting angle, liquid volume injected into the thoracic aorta, as well as the ejecting time in one cardiac cycle. Lastly, but not the least, these experimental results were verified through PC-based numerical simulation under those same simulation conditions, which contributed to achieving better drug perfusion ratio into target vessel in clinical practice through providing empirical data along with theoretical foundation.