Quantitative Assessment Of Hemodynamics In Cirrhosis Portal Hypertension With PC-MRI In A Phantom And Clinical Study

Quantitative assessment of hemodynamics in cirrhosis portal hypertension was studied in a phantom and clinical application with Phase-contrast MR imaging(PC MRI). PC-MRI was proved to be an accurary and practical flow measurement technique in a flow phantom. The flow in the portal vein in healthy controls were examined by using Cine PC MRI versus color Doppler US, the results showed Cine PC MRI could reflect normal liver function. Assessment of hemodynamics in cirrhosis portal hypertension and in healthy controls with Cine PC MRI versus 2D PC MRI, the results showed that Cine PC MRI was more accurary than 2D PC MRI while 2D PC MRI was better correlated with Cine PC MRI in cirrhosis portal hypertension. The correlation between hemodynamics and Child —Pugh grade, variceal hemorrhage or pressure of portal vein with cirrhosis were analyzed, which proved that PC MRI could be used to evaluate the degree of portal hypertension in cirrhosis patients and the high hemodynamic level in portal system was the elementary cause of upper gastric bleeding. Both eNOS and VEGF dominatingly expressed in the endothelium of the portal vein system, which implicated that the changes of vein structure played a very important role in portal hypertension patients.