| Introduction: Chronic stress affects people daily life ,with incapable avoidance, which all life need for survival and development. Profundily knowing disease mechanism of chronic stress, will help to study prevention and cure measure step, thus protect human body and mind health. Along with severity intense competition ,more and more illness mostly relative to chronic stress on depression increase day by day .Chronic stress can give rise to organism nerve—incretion—immunity system extensive changes, among them, center neuron system plasticity changes is one of cause leading to all kinds of stress reaction. Hippocampus is main regulate nerve centre and suffered centre, and hippocampus keep in close contact with amygdala on learning and emotion . Thus , synapse plasticity changes of amygdala and hippocampus may be organismic expressional inter mechanism during chronic stress reaction. For this reason, it is very important to guide clinic practice to study the relation between depressed animal model of chronic stress and medicine of regulating chronic stress ,directly researching from in nerve cell synapse plasticity aspect on structure and function.Objective:The task consisting of two parts-theoretical study and experimental study is to discuss chronic immobilization stress leading to mechanism of center nerve system synapse plasticity changes on aspect of structure and function by changes in hippocampus and amygdala .The research is to study the change rule of excitability glutamic acid repcetor NMDAR(N-methyl-D-aspartic acid receptor)-mainly subunit NMDAR2A(NR2A) and NMDAR2B(NR2B)and synapse growth associated protein GAP-43 and Nogo-A during chronic immobilization stress ,, interposing them with xiaoyaosan, observing accommodating function in two nerve nucleus, and hoping open out mechanism of chronic immobilization stress affecting synapse plasticity and accommodated mechanism of chinese traditional medicine compound xiaoyaosan regulating liver stagnation syndrome.Methods:... |
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