The Experimental Study Of Curative Effects And Molecular Mechanisms Of Chinese Compound Herbs Of Anti-fibrosis Ⅰ On Rat Hepatic Fibrosis

Hepatic fibrosis is the inevitable mediate stage and a common pathological process of varied chronic liver disease to cirrhosis. Hepatic fibrosis is a dynamic state between matrix production and degradation, and results in excessive deposition of extra cellular matrix (ECM) components, especially typeⅠ,Ⅲ, IV collagen. The pathological characteristics of hepatic fibrosis are hyperplasia and sedimentation of fibrous tissue in portal area and hepatic lobules, but the interlobular septum does not form. If the pseudolobuli have formed in liver tissue, septum has appeared in the central veins area and portal area, and the normal construction of liver has been demolished, the disease has developed from the phase of hepatic fibrosis to the phase of cirrhosis.Now the study on the mechanism of the hepatic fibrosis has been developed quickly. The factors causing the hepatic fibrosis (e.g. Virus, alcohol, parasite, copper and iron ect.) can activate the hepatic stellate cells(HSC). The activation of HSC, which may result in their spontaneous proliferation with a strong fibrogenic activity and abnormal deposition of ECM, are the main pathogenesis. The HSC play an important role in the development of the hepatic fibrosis to the cirrhosis. A prevalent opinion is that hepatic fibrosis is a reversible disease and can be reversed by positive treatment, but the cirrhosis usually is thought unreversed.Lots of data have indicated that the activation of HSC is the cytological base and central link of the hepatic fibrosis. Activated HSC are main cells synthesizing ECM. Thus HSC are chosen to be remedial target for much more anti-fibrosis medicaments. Some cytokines play an important role in the HSC activation. Many studies showed that transforming growth factor-β1(TGF-β1)...