Investigation On Autoimmune Features In Patients With Chronic C And The Association With PEG-IFN α-2a Treatment

Part IAnalysis on autoantibody and autoimmume disease in patients with chronic hepatitis C.[Objective] To analyze on the relationship between autoantibody , autoimmune disease and HCV infection, HCV genetypes and its clinical features.[Methods] Sandwich hybridization microplate and fluorescence quantification PCR and Indirect Immunofluorescence were used to detect HBV-DNA, HCV-DNA,HCVgenotype and ANA,SMA,AMA,LKMA1,TGA,TMA in CHC patients with /without autoimmune disease CHB patients.[Result] 116 patients (32.40%) with autoimmune autoantibody and 20 patients (5.59%) with autoimmune disease were found in 358 CHC patients. 29 patients (8.80%) with autoimmune autoantibody was found in 330 CHB patients, none with autoimmune disease was found in CHB patients. There was no significant difference on age, sex and duration of disease between CHC patients with and...