Preparation Technology And Evaluation Of CTS/ALG Microspheres As A Novel Hemostatic Agent

Objective to explore a way to make a new chitosanbased microspheres, which might be used as a novel hemostatic powder. Methods The emulsification and cross-link was chosed as preparation process; the hemostatic efficiency of MS and its accelerating effect on wound healing were evaluated when the MS stoped the bleeding and became hydrogel; Finally, the biocompatibility of MS was explored. Results The MS presents white powder, the loose construction makes its easier to absorb the water when it meet with body fluid. The surface of MS is coralloid under SEM. The bleeding times were significantly decreased in the MS treated group vs the control group. MS-treated wounds showed an earlier epithelialization. The CTS/ALG-MS was safety and showed well biocompatibility except a 2nd grade cytotoxicity. Conclusion CTS/ALG-MS is provided with favorable hemostatic efficiency and definite accelerating effect on wound healing. it might be a novel hemostatic powder, and deserve farther exploitation as HD for first aid in the battlefield, if we can improve its biocompatibility.