Clinical Trial Research On The Effects Of Aprotinin On Hemostasis And Inflammatory Response In Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery

Objective To study the effects of aprotinin on hemostasis and inflammatory response in patients undergoing off-pump coronary artery bypass graft surgery (OPCAB) perioperatively.Method This was a randomized double-blind design. Thirty nine patients scheduled for OPCAB were divided randomly into 3 groups: the control group (C), full-dose aprotinin group (A_H) and half-dose aprotinin group (A_L). A_H: 2×10~6 KIU aprotinin dissolved in 100 ml saline were infused intravenously during 30 min after induction, and then titrated 0.5×10~6 KIU/h up to the end of the operation; A_L: half dose of the A_H group; C: no aprotinin was infused. Specimens of plasma or urine were collected irrespectively at 5 time points: preoperatively (T1), 0.5h after the completion of vascular anastomosis (T2), 2h postoperatively (T3), 6h postoperatively (T4), 18h postoperatively (T5). The following parameters were measured, including (1) coagulatory indices: urinary fibrinopeptide A (uFPA), D-Dimer (D-D), tissue-plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and α-granule membrane...