Identification Of Myocardial Viability By ～(18)F-FDG Positron Emission Tomography In Patients With Myocardial Infarction

PurposeDifferentiating myocardial scar from viable but ischemic myocardium in patients with myocardial infarction is very important for the clinical identification of patients who will be of benefit from revascularization. This study was to assess the value of ¹⁸F-FDG metabolic imaging with a Chinese Positron Emission Tomography (PET) in identification of myocardial viability.MethodPET imaging using F-18-deoxyglucose (¹⁸F-FDG) and ^99mTc-MIBI perfusion SPECT were performed in 90 consecutive patients ( age 55.8±9.6 yr. ) with previous myocardial infarction(OMI). 76 patients( pts) had coronary artery angiography, among them 10 had single -vessel disease , 23 had two -vessel disease and 43 had three-vessel disease. 45 pts underwent coronary artery bypass grafting (CABG) and 7 pts underwent percutaneous transluminal coronary angioplasty(PTCA). Before and after revascularization (73 ± 80 days), the left ventricular global and regional function were evaluated with echocardiography in 36 pts (Group A). Before and after revascularization (89 ± 54 days), the myocardial perfusion imaging and echocardiography were performed in 24 pts (Group B).The ¹⁸F-FDG PET imaging was performed using the Chinese PET-B03 system, the myocardial perfusion imaging was performed using Siemens multiple SPECT 3.The left ventricle was divided into 9 segments .The imaging of ¹⁸F-FDG and ^99mTc-MIBI were analyzed using the same score system (0= normal uptake ; 1 = diminished uptake ; 2= significant diminished uptake, 3=absent uptake). The following definitions of regional viability were applied:...