Evaluation On Gated ^99mTc-MIBI SPECT Myocardial Tomography Imaging For Detecting Myocardial Viability With The Intervention Of Nitroglycerin

ObjectiveTo assessing the value of detecting myocardial viability with myocardial tomography imaging, wall motion (WM) and wall motion thickening (WT) obtained by gated 99mTc-MIBI SPECT myocardial tomography imaging after intravenous injection of nitroglycerin (NTG) in patients with myocardial infarction. Methods41 patients with myocardial infarction were treated by routine resting gated stage 99mTc-MIBI SPECT myocardial perfusion imaging and underged the intravenous infusion of nitroglycerin (NTG) in compliance before the intravenous injection of 99mTc-MIBI once again after rested gate 99mTc-MIBI SPECT myocardial perfusion imaging after 24 hours, and the changing were comparated and analyzed of segmental myocardial perfusion and regional wall motion (WM) and wall motion thickening (WT) .Results1.The results of perfusion to improving: 41 patients with a total of 820 myocardial segments, of which 491 myocardial perfusion abnormality, in which segment 162 to reducing the radioactivity and the the 157 segments which radioactive seriously reducing, 172 segments of radioactive defect; And gated 99mTc-MIBI SPECT scintigraphy after intervention by NTG which were detected 384 (46.83%) segments which perfusion abnormality, in which segment 151 to reducing the radioactivity and the 143 segments that radioactive severely reducing, 90 segments of radioactive defect, NTG intervention, complete and then filled with 107 segments 21.79%, partly refilled with 82 segments of 16.70%,overall improvement segments of the total abnormal segments were 38.49%[(107+82)/491];2.There is significant correlation between the segments myocardial perfusion values (the percentage of relative 99mTc-MIBI uptaked) and the changing of the WM and WT obtained by gated SPECT, and the coefficient r=0.53,r=0.49 and r=0.74,r=0.72 respectively intervented by NTG before and after;3.To comparing the changing of WM and WT which were intervented by NTG before and after, which the p >0.05 of WM that was considered it have no statistically significant,It have no singnificant improvement in intervented by NTG, While WT the p<0.001 that was considered statistically significant,wich the WT have singnificant improvemen after NTG inventions. So the WT have more singnificant value on evaluating the function of myocardium contraction than WM.Conclusion1. Using information obtained by the gated 99mTc-MIBI SPECT myocardial perfusion imaging by NTG intervention can be quantitatively gating analysis and evaluation of myocardial infarction in patients with infarction location, area of all volume percentage and myocardial viability;2. Using information between WM and WT obtained by the gated 99mTc-MIBI SPECT myocardial perfusion imaging by NTG intervention can improve veracity and the rate dectected; Both of the WM and WT evaluat myocardial viability and the function of myocardium contraction,of which the WT has more value.3.Combining the information between images and WM and WT obtained by the gated 99mTc-MIBI SPECT myocardial perfusion imaging by NTG intervention can be quantitatively gating analysis and evaluation of myocardial infarction and the function of myocardium contraction of global and region roundly in patients with myocardial infarction, and that judge some patients can be obtain benefit from undergoing after treatment of coronary revascularization;4.NTG intervention gated 99mTc-MIBI SPECT myocardial perfusion imaging is safe, convenient, non-invasive, and gain some important information such as images and WM and WT in once opration, meanwhile play an important guiding role in therapy and risk stratification. for patients with coronary artery revascularization.