The Role Of Adrenoceptor Subtypes Gene Expression In The Pathogenesis Of Hypoxic Pulmonary Hypertension And Right Ventricular Hypertrophy

Chronic obstructive pulmonary disease is a common cause of losing health and a kind of disease with high morbidity. Sustained constriction of small intra-pulmonary arteries and the remodelling of vascular structures induced by airway obstruction and alveolar hypoxia led to pulmonary hypertension and corpulmonale. The results of our previous studies on the changes of adrenoceptor (AR) subtypes and their mRNAs in lung tissues and pulmonary arteries implied that these changes might play an important role in the pathogenesis of hypoxic pulmonary hypertension(HPH). The intrapulmonary arteries especially arterioles are more important for vasoconstricting response to hypoxia , but it is very difficulty to isolate them from the lung. Therefore; what the gene expressions of AR subtypes in hypoxic rat intrapulmonary arterioles(IPA) is still remained unclear. In addition,myocardial cellsalso respond to hypoxia and evolve myocardiol hypertrophy, but its pathogenesis is not aware yet.