Study On Pathogenesis Of Experimental Emphysema And Pulmonary Hypertension In Hamsters And Observation In Preventive And Therapeutic Effect Of Chinese Herbs 814

Chronic obstructive pulmonary diseases (COPD) is a series of chronic and progressive airway diseases, including emphysema and chronic bronchitis etc. Many advances were achieved in research of pathogenesis, prevention and therapy of COPD, but pathogenesis of COPD has not been completely understood and there are not ideal approaches to prevent and treat it either. So far the majority of researches considered that imbalance of proteinase/antiproteinase system, airway inflammation, immune abnormality and oxidative damage were responsible for inducing, maintaining degradation of lung parenchyma and promoting development or progress of COPD. Recent year's study proved that pulmonary surfactant played a major role in maintaining airway stability, immunomodulation and barrier function etc. Dysfunction in composition and function of pulmonary surfactant in COPD might be one of the mechanisms leading to increasing airway resistance and be concerned with development of COPD. Therefore, improvement of endogenous surfactant is helpful in relieving symptom of COPD and meliorating effect of therapy.Chinese herbs 814 is a new drug developed by Blood Diseases Institute of Chinese Medical Scientific Academy. Previous researches showed that it was able to obviously decrease pulmonary hypertension, improve circulation of heart and brain, inhibit bacteria, anti-inflammation and reinforce cell-mediated immunity etc. On one hand, our researches established Syrian golden hamsters model of emphysema and pulmonary hypertension to observe the effect of herbs 814 on pulmonary artery pressure, pulmonary tissue structure, NO in serum, pulmonary extracellular matrix (collagen and fibronectin) and pulmonary surfactant (phospholipids and proteins). On...