Protection By New Compound FLZ And Ginkgo Biloba Extract (EGb761) Against The Oxidization Of Human Low Density Lipoprotein And Its Cytotoxicity To Macrophages And Vascular Endothelial Cells

The complications of cardiovascular and cerebral vascular due to atherosclerosis are one of the major causes of mortality in clinics. Vascular endothelium lesion is an initial factor of atherogenesis, and oxidized low density lipoprotein(ox-LDL) plays an important role in the injury of endothelium. Ox-LDL can be rapidly uptaken by macrophages and accumulated within the cells, which leads to the formation of foam cells and damages of vascular endothelial cells and smooth muscle cells. Some antioxidants can delay the atherosclerotic process. FLZ is a new compound which was shown to have strong antioxidative activity in vitro and in vivo, and the extract from Ginkgo biloba (EGb761) is a widely used antioxidants in clinics. Therefore, with regard to the pathophysiological and biochemical mechanism of atherogenesis and development, the protective effects of FLZ and EGb761 on the...