Role Of Retinoic Acid And RARβ In Form Deprivation Myopia

Myopia is a most commonly disease in ophthalmology, which greatly affects people' s life. The incidence of myopia is increasing year by year. After studied of more than 200years, there is still no satisfactory explanation to myopia pathogenesis.It remains urgent task. At present, form deprivation myopia (FDM) has been hotspots on mechanisms of myopia. The rate of eye will accelerate its growth and become highly myopia if deprived of form vision. Much work has gone into identifying what chemical signals might participate in the retina s influence on eye growth. Studies of FDM show that retinoic acid(RA) is also considered to be a candidate for a molecule that regulates the ocular enlargement in FDM, but the particular mechanism is not clear.The Vitamin A derivative, retinoic acid, affects the proliferation and differentiation of some types of cells, including photoreceptors and amacrine cells. RA is known to be teratogenic and is thought to be an important factor in ocular development. In both mice and chicks,...