Intracoronary Implantation Of Autologus Bone Marrow-Derived Mesenchymal Stem Cells After Acute Myocardial Infarction In Porcine

IntroductionDespite application of pharmacotherapeutics and mechanical interventions, cardiomyocytes loss in the area supplied by the infarct-related artery during the period of acute myocardial infarction (AMI) cannot be regenerated by nature and form non-contractile scar through fiber tissues. Remodeling of the left ventricle and aneurysm formation in survivors after the acute phase is the leading cause of infarct-related heart failure and death. As a brand-new treatment, the cellular replacement therapy becomes an ideal strategy to reverse myocardial remodeling repair myocardial tissue by using bone marrow-derived cells. Multipotential mesenchymal stem cells (MSCs) have been discovered to exhibit regenerative properties for damaged organs, are ideal seed cells for recruiting the loss of cardiomyocytes due to their strong proliferative capacity, easy acquisition, and multi differentiating potential. Using human MSCs on therapeutic cardiomyoplasty could be promissing in the future.Though great progresses have been made in the field of cellular...