| Objectives:To investigate the effects of PCI time on left ventricular remodeling after acute myocardial infarction.Methods:We conducted a randomized study involving 65 patients with first ST-elevation myocardial infarction admitted in our hospital and all the patients were assigned to routine PCI and stenting with optimal medical therapy. According to the time that PCI was performed, the patients were divided into three groups:early PCI(<12hours), late PCI(12～72hours)and selectively PCI(>72hours). All the patients were performed echocar-diography at discharging and 6 months after the AMI. We analyzed the echocardiographic findings and compared the left ventricular ejection fraction(LVEF) and the left ventricular end-diastolic diameter (LVEDD).Results:1) The patients'heart function of early PCI group is superior to the other groups at discharging (56.38VS50.87%, P<0.05; 56.38VS 52.59%, P=0.05).There was no statistically significant difference in the LVEF after a 6 months follow-up between the three groups.2) No significant difference in LVEDD was found between three groups both at discharging and 6 months.3)In the early PCI group, the LVEDD obviously decreased(48.14±3.53mmVS46.36±4.20mm, P<0.05) after 6 months compared with that before discharging.4)Subgroup analysis:the advantage of early PCI group in the patients with anterior myocardial infarction is still exist. Worthy to note is that the LVEDD in selectively PCI group is larger than late PCI group both at discharging and at 6 months after AMI.Conclusions:Early PCI could obviously improve the cardiac function and left ventricular remodeling of patients with acute myocardial infarction. For the patients with anterior myocardial infarction, late PCI is superior to selectively PCI in improving ventricular remodeling. We could recommend an earlier PCI strategy(late PCI) for patients with acute anterior myocardial infarction who have missed the opportunity of early PCI.
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