Functional Studies Of Annexin Ⅰ In Human Pancreatic Cancer

As a common cancer with a yearly increasing occurrence rate, pancreatic cancer presents unsatisfied outcomes of current therapies and an extremely poor prognosis, due to its high malignancy and a lack of early specific diagnostic methods. To solve the problem, the essential way is to find new therapeutic targets and diagnostic markers. Like all the other cancers, the oncogenesis of pancreatic cancer is also a complicated pathological process involves many factors, many genes and many stages. The interaction between oncogenes and anti-oncogenes plays a critical role in it. As a member of annexin family, a Ca²⁺ binding protein family, Annexin I plays important role in many physical process, it modulate cell functions , such as signal transduction, DNA replication, cell transformation, cytoadherence, exocytosis and formation of calcium channel. Abnormalities in signal conduction and disorders in cell cycle will lead to malignant proliferation of cells. The close relation between Annexin I and various tumors and the abnormal expression of Annexin I in different tumors have been confirmed by many studies. Annexin I has already become one important cancer biomarker of lung cancer and other cancers. Annexin I also modulates drug resistance in some...