Studies On The Chemical Constituents And Bioactivities Of Medicinal Fungi Fomes Officinalis And Medicinal Plant Trachyspermum Ammi

Formes officinalis, a fungus of Fomes genus in Polyporaceace family, is a wood rotting fungus which is found on the trunks of living or dead coniferous trees in the northern regions of China and in the Pacific Northwest United States, Canada and in Europe. It is traditionally used in Chinese Uigur prescription to treat cough and asthma. A variety of triterpenes from this fungus have been characterized since it was first studied in 1804. In order to obtain a more comprehensive understanding of its effective physiological constituents, in this doctoral dissertation, the systematic phytochemical and pharmacological studies have been carried out.Twenty-seven compounds were isolated from the ethanol extracts of its dried sclerotium. On the basis of various modern spectroscopic analysis(IR, UV, MS, ¹HNMR, ¹³CNMR, 1H-1HCOSY, HMBC, HMQC, NOESY) and classical chemical methods, twenty-four compounds were determined, of which nine were new, six were isolated from this fungus for the first time.The new compounds are all lanostane-type triterpenes, their structures were determined as follows: Fomefficinic acid A (24-methylene-3-oxo-lanosta-8-en-21 -oic acid), Fomefficinic acid B [3α, 15α-dihydroxy-24-methylene-lanosta-7, 9(11)-dien-21-oic acid], Fomefficinic acid C (3α,15α-dihydroxy-24-methylene-lanosta-8-en-21-oic acid), Fomefficinic acid D (15α-hydroxy-24-methylene-3-oxo-lanosta-8-en-21-oic acid), Fomefficinic acid E [15α-acetyloxy-24-methylene-3-oxo-lanosta-7, 9(11)-dien-21-oic acid], Fomefficinic acid F (15α, 26-dihydroxy-3-oxo-24-methyl-...