Refine Mapping And Susceptibility Genes Study Of PSORS9 Region In Chinese Han Population

Part â… Follow-up Analysis of PSORS9 in Chinese Families: Refine the Critical Interval to Chromosome 4q31-32 and Provide Strong Linkage Evidence for early onset patients Background Psoriasis is a chronic inflammatory skin disease affecting approximately0.1-5% in the general population. Family clustering of the disease is well established andeight loci designated PSORS1-7 and PSORS9 with further 11 undesignated loci havebeen identified as potential psoriasis susceptibility loci. Previously genome-wide scansby our group have provided strong evidence for major psoriasis susceptibility loci 6p21(max NPL score =4.58, p=0.000032) and suggestive evidence at 4q28-32(max NPL score=3.69, p=0.00033) in 61 Chinese Han multiplex psoriasis vulgaris families. The latter isdenoted PSORS9. The confidence interval of this localization spans on a broad geneticregion, estimated to be 35 cM. This region is a priori expected to contain three hundredgenes.Objective To further refine the location of PSORS9 and narrow this critical linkageregion.Method We genotyped 151 multiplex families including the 61 pedigrees used in ourprevious genome-wide linkage study for 13 polymorphic microsatellites flanking theinitial peak linkage marker. We also incorporated mean age at onset of each family as a...