Experimental And Clinical Study Of Dobutamine-Metoprolol Stress Echocardiography Combined With Doppler Tissue Imaging In Detecting Coronary Artery Disease

Objective1. To evaluate the value and mechanism of Dobutamine-Metoprolol Stress Echocardiography (DMSE) on ischemia segments of miniswine and patients with coronary artery disease (CAD).2. To assess the value of quantitative tissue velocity imaging (QTVI), strain and strain rate imaging (SRI) combined with DMSE in detecting miniswine and patients with chronic coronary artery disease.3. To assess the features of left ventricular regional myocardial motion during isovolumetric phase in DMSE detection of coronary artery disease.4. To evaluate the predictive value of SRI combined with DMSE in detecting regional myocardial function of ischemia segment. Methods1. Model of chronic coronary artery stenosis Twenty-two miniswine were performed with thoracotomy and pericardiectomy. Ameroid constrictor was then implanted around the left circumflex artery (LCX) proximal to the first marginal branch. Coronary angiography (CAG), myocardial perfusion tomography, conventional Echocardiography and DMSE were performed before and 3 weeks after the surgery. At the endpoint of study, all animals were killed and pathological studies were performed.2. Clinical study DASE was performed in 72 patients with suspected CAD. All the patients received DASE and CAG in two weeks. One month after percutaneous coronary intervention, Echocardiography were...