The Expression Of Aurora-A And The Effect Of Aurora-A To Telomerase Activity In Ovarian Cancer

Ovarian cancer is a kind of serious gynecological malignancy, which can severely impire the women's health. The incidence rate and mortality rate of ovarian cancer were higher and higher in the world. Currently, ovarian cancer is the first leading cause of gynecological cancer-related deaths in China. Because the most patients were diagnosed at late phase, it is poor effect and bad prognosis. Finding a new prognosis marker and molecular therapeutic target for ovarian cancer are needed.Aurora kinases is a novel family of serine/threonine kinase that have been indentifide as key regulators of the mitotic cell divesion process including the regulation progresses of centrosome function, bipolar spindle assembly and chromosome segregation progresses. Aurora-A is an important mumber of the serine/threonine kinases family and the kinase gene is located in the 20q13.2 chromosome region that is frequently amplified in many human cancers such as colorectal, breast, bladder and tongue cancer. Aurora-A gend has been indentified as a novel oncogene due to its overexpression detected in many human tumors as well as overexpression has been shown to cause centrosome amplification, chromosome instability and cell tumorigenic transformation in vitro and vivo.Telomeres, the DNA-protein complexes at the ends of eukaryotic chromosomes, are protective against genome instability-promoting events, The lenghth of the...