Proteome Analysis Of Rat Lung Of Transplantation

Background Lung transplantation already has become an effect method to treat pulmonary disease. With the technology improvement of lung preserve, surgical operation, anaesthesia way, and the application of high performance antibiotic and the development of immuno-supperssive agent, lung transplantation has had more progresses. Furthermore, the quality of life has obviously improved in the patients of lung transplantation. However, donor deficiency, postgraft rejection and obliterative bronchiolitis are still the important problem to influence the quantity of lung transplantation and long term survival of lung transplantation patients. Especially, the immunological rejection of lung transplantation is all the time the key point of long term survival of lung transplantation patients. The exact pathogenesy of lung post-transplantation rejection is incompletely understood. International Heart-Lung Transplantation Institute convoked the second conference in Pittsburgh in March, 1995 and indicated the important evidence of pathological diagnosis of lung transplantation acute rejection is the lymphomonocyte infiltration in pulmonary interstitial and around bronchus and vascular, but the concomitance airway inflammation and its grade should state during grading of lung transplantation acute rejection. Chronic rejection includes two ways: ( 1 ) Obliterative Bronchiolitis(OB); (2) Vascular scleratheroma. Chronic rejection of lung transplantation is bronchiole proliferation pathological process of dominical immune factor and multiple factor and displays persistent region inflammation reaction, bronchiole epithelium injury, endomembrane hyperplasia, fibrous connective tissue proliferation,...