The Preliminary Study On Gene Expression Profiling Of Endometrial Carcinoma Between Estrogen Dependent And Independent Types

In the United States, endometrial carcinoma is the most common female genital cancer and ranks fourth in overall cancer incidence following breast, lung, and colorectal cancers. Approximately 36,100 new cases and 6,500 deaths associated with this cancer were reported in the year 2000. Similarly, endometrial carcinoma is also one of the popular female cancers in china.It is generally accepted that the genesis of endometrial carcinoma is associated with persistent unopposed estrogen stimulation. So endometrial carcinomas are a type of generally estrogen dependent cancer which is often been found and have a good outcome, and its survival rate of 5 years is up to 70%. However, some patients, especially those who are postmenopausal, show no association with excess exogenous or endogenous estrogen. Furthermore, if these patients are treated by hormone, they will have a poor prognosis.Over the past several years, a dualistic model of endometrial carcinoma, first proposed by Bohkman, has become increasingly accepted In this model, Type I or endometrioid carcinomas result from model, Type I or endometrioid carcinomas result from are typically perimenopausal and often have risk factors that include obesity, hyperlipidemia, nulliparity, diabetes mellitus, hypertension, and late-onset menopause. Unopposed estrogen results in hyperplasia and ultimately atypical...