Studies Of Shengjin Granule Curative Effect And Laboratory Experiment To Primary Sj(?)gren's Syndrome

Sjogren's syndrome(SS)is a chronic general immunological disease characterized by involved exocrine gland, especially saliva gland and lacrimai gland. The principal pathologic change in the exocrine glands is lymphocyte infiltration. It may damage other organs and result in various clinical manifestations. More than 90% of the patients are female. The main age at onset is 30-40 years old. A domestic material show the incidence of SS was 0.77-0.29 (according to different diagnostic criterion). It indicate SS is not a unusual disease. Despite disease is common, the exact cause and mechanism of which remain unclear. There has not efficacious treatment to this day.However it shows fixed superiority in treating this disease by TCM. We observe the clinical therapeutic outcome of Shengjin Granule treating PSS, and research into its TCM etiology ,mechanism and treatment. We advance absence and obstruction of flowing and dispersing of jinye is the fundamental pathologic change of SS, Yin-deficiency and channel stagnation is the primary patho-mechanism of SS. From all these, we propose the treatment of PSS be focused on lung.In experiment study it is observed that Shengjin granule work on excretive of rabbits saliva and tears, and observed that shengjin granule infective on excretive of rats saliva and tears make use of rats model. Base on it, carry out the pharmacological study from immune and anti-inflammation and so on. As a result, high and medium dosage Shengjin granule obviously augment excretive of rabbits saliva and tears, and contradict the atropine restrain .Low dosage also advance gland excretive but effective time is later high and medium dosage group; Make use of thyroxin and reserpine copy the model of "yin-insufficiency and hyperthyroidism". Observed the effect of Shengjing granule on rats model saliva excretive, drink, avoirdupois and appetite. As a result, Shengjin granule can ameliorate rats symptoms, for example, salvia excrete reduce, drink increasing, appetite increasing and avoirdupois decline. Anti-inflammation study makes sure that Shengjin granule contradict urgent inflammation feebleness and better on chronic inflammation. At the same time, adjust correlative cytokine well; toxicity study approve that it is safety.Clinical research 58 PSS patients were randomly divided into treat group(Shengjin Granule group , 38cases)and control group(general group , 20cases). The effective rate was 84.21%, which significantly surpassed the effective rate of the control group(45 %), after 3 months treatment. Shengjin Granule can ease local and general condition, such as dry mouth, dry eye, fatigue and constipation, and so on. Also it can lower ESR and immunoglobulin, regulating cytokine levels(sIL-2R)and improve secretion of lacrimal gland. With respect to these points, the treat group is better than the control group, conclusion: Shengjin Granule may remitted Symptoms , Stabilize condition and improve laboratory markers.The study result shows that Shengjin Granule has a fixed Clinical benefit in patients with primary Sjogren's Syndrome. It also has functions of regulating immune, stabilizing condition and improving symptoms. The study has fixed...