The Neuroprotection Of Lidocaine By Injecting Into Cisterna Magna In A Rabbit Model Of Subarachnoid Hemorrhage

Objection: In this study,we would investigate whether it had the prevention of cerebral vasospasm and hippocampus tissue damage by intracisternal delivery of Lidocaine in a rabbit model of subarachnoid hemorrhage. Methods:Thirty New Zealand white rabbits were randomly allocated to sham group(sham), subarachnoid hemorrhage group(SAH), and Lidocaine therapy group(Lidocaine) (n = 10, respectively) . All animals underwent operation under general anaesthesia. 1.5ml autologous nonheparinized arterial blood was injected into cisterna magna in SAH group and Lidocaine group, and 1.5ml saline into cisterna magna in sham group respectively. Thirty minutes after SAH, 0.1ml saline was injected into cisterna magna in sham group and SAH group, and 0.1 ml 2 percent Lidocaine into cisterna magna in Lidocaine group, respectively. 72 hours after SAH all animals were deeply anesthetized and killed by perfusion-fixation. Their basilar arteries and hippocampus tissue were processed for morphometric analysis. The level of endothelin(ET), calcitonin gene-related peptide(CGRP) in plasm and interleukin-6 (IL-6) in serum was...