Cloning Sequencing Of 1A12-McAb Varible Genes And Expression Of 1A12V_H Gene In E.coli And In Insect Cells.

Antibody therapy holds great promise for the treatment of viral infections, cancer, and autoimmune disorders. Murine monoclonal antibodies (McAbs) are relatively easy toproduce but are severely restricted for therapeutic useby their immunogenicity in humans. Product ion of human M-cAbs has been cloned and transfected into lyphoid cells,E.coli cells or mammals. Antibodies can be expressioned and secreted as single domain antibodies, single chain antibodies, chimeric abtibodies or humanized antibodies.Herpes simplex virus (HSV) causes oral/facial, genitalle-sions, and cerebral necrosis.The glycoproteins of HSVare present on the virus envelope and involved in virus penetration, fusion with cell mambraines, egress from infected...