An Experimental Study On Radioimmunotherapy For Xenografts Of Human Esophageal Carcinoma In Nude Mice

There has been a noticeable progress in the study of radioimmunotherapy for malignant tumors in recent years. Its preliminary clinical trial has turned out quite encouraging based on the deepening preclinical experiments, especially in the treatment of solid carcinomas such as liver carcinoma, lymphoma, melanoma, gastric carcinoma, carcinoma of colon, and ovarian carcinoma, etc. However, radioimmunotherapy for esophageal carcinoma has not been found in the literature. In the present study, the immunonuclide was prepared with ¹³¹I-labeling monoclonal antibody MGb₂, and comprehensive evaluation on its immune feature, targeting ability and therapeutic effect in nude mice as human esophageal carcinoma xenografts was made for the purpose of providing an experimental basis for its clinical application. The study was as follows:1.Purification and specific test of monoclonal antibody MGb₂:...