Study On Pathology And Injury Mechanism In Liver Transplantation

Background: Improvements in preservation of donor organs, surgical technique and immunosuppressive therapy have greatly improved the outcome following liver transplantation, and this is now well established as a method for the treatment of many incurable liver diseases.But many elements including preservation/reperfusion injury, rejection, opportunistic infections, drug toxicity, recurrence of the original disease for transplantation will effect long survival. Biopsy has been considered as the most efficient method for diagnosis.Further study should be done since their inconsistent description of pathologic characteristics and blurred differential diagnostic features.The induction of immune tolerance has been considered as the efficient method for long survival. Study on the injury mechanism of acute rejection is the basis for immune tolerance, Hence, one of the key reseach have been focus on the injury mechanism of acute rejection.Objective: To investigate the allograft liver pathological characteristics and the mechanism of acute rejection in liver and renal transplantation.Methods: All the biopsies after liver transplantation from Franche-comte university in France were collected and analysed, amounting to 122 cases with 272 biopsies and 69 biopsies in centrilobular changes were analysed. 47 biopsies microabscesses were reviewed, The histological features showed the number of neutrophils in each microabscess and the number of microabscesses per high scope of biopsy for the MMA syndrome and Cytomegalovirus (CMV) infection. The age and time of the occurance of micro-abscess for the MMA stndrome and CMV infection...