| The immune system has two complementary arms:one is called the innate immune system,the second is the adaptive or antigene-specific immune system. The human innate immune system has many cellular elements that include granulocytes, monocytes, macrophages,natural killer cells,mast cells,eosinophils,basophils and red blood cells . More and more studies have confirmed that the innate immunity function changes of RBCs are involved in the nosogenesis,development and pathology of many diseaes ,for instance tumor,autoimmune disorders and hematologic disease. Determination of the changes of the innate immunity function of RBCs has important significance in clinically diagnosis,observation of theraputic effect and investigation of pathogenesy of these disease. We studied the changes of the number of CR1 of red blood cells(ECR1),the change regularity of red blood cell CR1 genomic density polymorphism ,changes of erythrocyte innate immune adhering function and the influence of red blood cells on the killing activity of NK cells of patients with hematologic and lymphoid neoplasms.The results indicated that the number of ECR1, the changes of erythrocyte innate immune adhering function and the influence of red blood cells on the killing activity of NK cells are all decreased significantly in the patients with hematologic and lymphoid neoplasms comparing to those of normal controls.We reach the conclusion that the innate immunity function changes of RBCs maybe involved in the nosogenesis,development and pathology of hematologic and lymphoid neoplasms.Enhancement of the immunological function of RBCs may play an important role for us to overcome hematologic and lymphoid neoplasms.Part 1 The number of ECR1 of patients with hematologic and lymphoid neoplasmsOBJECTIVE To detect the number of ECR1 of patients with hematologic and lymphoid neoplasms and that of mormal controls. METHODS Red blood cells from venous blood are labeled by mouse anti-human CD35-FITC monoclonal antibody .
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