Clinical Study Of Additional Tong Xie Yao Fang In Treating Irritable Bowel Syndrome Of The Type Of Diarrhea

Irritable Bowel Syndrome is a chronic, recurrent attacking with intestinal movement dysfunction syndrome which is difficulty to be explained by anatomy, pathological and chemical examination. It is an intestinal functional disorder which excludes structural disease. It includes a serial of symptoms of abdominal pain, abdominal distension, ragouts, change of frequency of defecation and abnormal stool, mucous stool, and defective stool etc which related to defecation clinically. It attacks persistently or intermittently, but without structural disease through all kinds of examinations at present.The etiology and pathogenesis of IBS are complicated and have not been clarified completely, but the viewpoint has been developed from "merely power disorder" through many years to "the theory of brain-gut axis " suggested in recent years. Some persons thinks that IBS is the results of following factors affected each other including functional disorder of central nervous system, abnormality of visceral sense and motion, hormonal action of alimentary canal, psychological obstacle, genetic factor, intestinal infection and other enteric cavity factors etc. It represents the mode and viewpoint of "Biological medicine-psychological medicine-social medicine" of modern medicine. Others thinks that the nervous immune endocrinal cell of intestinal tract is a wholly regulated network and the pathogenesis of IBS is possibly related to the dysfunction of this network.We can' t explain the complicated symptoms of IBS with single pathological and physiological mechanism because of many related pathological and physiological factors .Also there are no one kind of medicineor single therapy can cure IBS completely nowadays.Therefore, according to the severity of symptoms of patients, seizure frequency and symptom type, following the principle of individualization, taking synthetic therapeutic measures including psychological treatment, food therapy and drug treatment. We should choose different therapy and drugs according to different people and take symptomatic treatment.In traditional Chinese medicine, Irritable Bowel Syndrome, (IBS) is categorized in abdominal pain, constipation and diarrhea. It can happen at any age, with great partial between twenty and fifty, and there is no remarkable difference between men and women. The incidence of disease is relatively high, account for 15% of total amount of crowds, about 1/3-1/2 of the Digest outpatients' clinic counts. Because the cause of disease has not been yet clear, there is no ideal treatment in Western medicine at present. Traditional Chinese medicine studies on this disease have made great progress with obvious advantage and definite curative effects is in recent years. Traditional Chinese medicine thinks: the disease location is the internal organs for the diarrhea type IBS. Due to the dredging of the liver qi, the spleen and stomach loose their transporting function, and the dysfunction of intestine is the main cause. The irregular flow of the liver qi causes the abdominal pain, and abdominal flatulence. Liver qi invading spleen and stomach causes the disorder of yang qi and turbidly of yin with the symptom of uncomfortable, abdominal and the intestines chirp. The dysfunction of the spleen causes the mixture of clear and turbid qi invading the intestine will cause diarrhea. There will be excess syndrome at the beginning and deficiency syndrome after long lasting sickness. The primary (ben) is deficient, and the secondary (biao) is excessive. Excessive secondary is caused by blood stasis, stagnation of qi, and incardination of liver and spleen. The primary deficiency is caused by asthenia and deficient yang of kidney and spleen.Purpose This research is based on the above, regarding the basic theory of traditional Chinese medicine as guidelines, using clinical patients as the research object, and random adoption method to observe the clinical curative effect and probing for treating IBS with Tong Xie Yao Fang.ObjectiveThrough clinical cases observation for the curing of irritable bowel syndrome (diarrhea type) by using Plus Tong Xie Yao Fang granula and a comparative analysis by using Tong Xie Yao Fang granula and Pinaverium Bromide Pill. And inquiry for the results for the purpose of providing academic basis for a wider application of Tong Fu-ning Pellet to cure IBS(01). MethodDivided 134 clinic and ward patients randomly into the Pluss Tong Xie Yao Fang group and the Tong Xie Yao Fang group and the Pinaverium Bromide group, in the Plus Tong Xie Yao Fang group , 66 patients taking Pluss Tong Xie Yao Fang granula orally three times per day with one bag each time. In the Tong Xie Yao Fang group, 26 patients taking Tong Xie Yao Fang granula orally three times per day with one bag each time .In the Pinaverium Bromide group, 42 patients taking Pinaverium Bromide (50mg)three times per day according to the specification. All groups stopped using other interrelated treatment medicines and were observed for one period of treatment (30 days per treatment). ResultAmong the 66 patients in the Plus Tong Xie Yao Fang group, 37 clinically cured, 18 cases with obvious curative effect, 7cases with effect, 4 cases without effect, total effective rate 93.94%. the 26 patients in the Tong Xie Yao Fang group, 10 clinically cured, 8 cases with obvious curative effect, 4cases with effect, 4 cases without effect, total effective rate 84.92%.Among the 42 cases in the Pinaverium Bromide group, 12 cured, 8 with obvious curative effect, 13 with effect, 9 without effect, total effective rate 78.57%. There is a marked difference (P<0. 05),by comparing the total effective rates between the three. ConclusionThe Plus Tong Xie Yao Fang granula and Tong Xie Yao Fang granula and the Pinaverium Bromide Pill all have definite effect for the treatment of IBS, but the Plus Tong Xie Yao Fang granula group has an obviously surpass than the other two groups. The Plus Tong Xie Yao Fang granula group has an obviously therapeutic effect for irritable bowel syndrome patient which have dissimilarity sexuality and dissimilarity age and dissimilarity course anddissimilarity pathogenic condition and even dissimilarity symptom expressional. This shows that plus Tong Xie Yao Fang has a better clinical effect than merely use Tong Xie Yao Fang or Pinaverium Bromide for the treatment of IBS. The plus Tong Xie Yao Fang could obviously improve the syndrome of irritable bowel syndrome, such as abdominal distension and stomachache and diarrhea. And also relieve the slime in the mucus piss and the intestines chirp and psychiatric symptom of the patient. There are no any adverse effect to patient in the course of clinic treatment .it certify the safe of The plus Tong Xie Yao Fang. And it also shows that it is safe to take Tong Xie Yao Fang granula in 30 days. The optimization course of treatment is about 7-15days when you take the Chinese medicine. The mechanism of Tong Xie Yao Fang can treat irritable bowel syndrome patient by adjust autonomic nerve and recover the functional disorder, improve motion of colon.