| Today, there is an increasing incidence of cerebral vascular disease with aging. Among them ischemia event is more popular than haemorrhagic one, especially the middle cerebral artery occlusion, a kind of ischemical brain disease, characterized by leaving various obstacles in speaking, motion and sense, and the changes of intelligence and emotion. At present, medical treatment for these disease is poor, no any real effective drug was recognized. Thus, it is an urgent task for us to look for a better preventive or/and treatable drugs.Radix salvia mitihorriza, one of the traditional Chinese medicine, first recorded in "SHENNONGBENCAOJING" more than two thousands years ago. With the mordern scientific technique, we extracted salvianolic acids from the water-components of the drug.Its basic structure is 3,4-hydroxybenzel lactic acid. The main component of salvianolic acids is salvianolic acid B. Several salvianolic acids were shown to have strong effect of antioxidation, such as salvianolic acid A, salvianolic acid B. According to the close relationship between oxidatation and ischemia, a study was carried out for observing the effect of total salvianolic acid(SAs) on cerebral ischemia, with comparing to VitE, and elucidating their mechanisms of action, both in vitro and in vivo system.In the present study, the model of middle cerebral artery occlusion in...
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